Skip to main content


Metabolism, diet and disease

To accompany their BMC conference series on Metabolism, diet and disease, this year with the special theme of cancer and metabolism, the two conference host journals, BMC Biology and BMC Medicine, have launched a thematic series of publications aimed at showing how basic research on the biochemistry, cell biology and genetics of metabolism can address the major health problems of cancer, obesity, cardiovascular disease, diabetes and insulin resistance, and how the therapeutic and nutritional implications can inform the clinical management and treatment of these diseases. The series includes original research, review, comment and opinion pieces, as well as interviews and Q&As, and we welcome further research submissions on these topics. (Video) The obesity-cancer connection. Panel discussion from 'Metabolism Diet and Disease' held in Washington DC, May 29-31 2012. The opinions presented by the panel are those of the individuals and do not represent an endorsement of any organization or product.

  1. Opinion

    Q&A: targeting autophagy in cancer—a new therapeutic?

    Macroautophagy (autophagy hereafter) captures and degrades intracellular proteins and organelles in lysosomes as a quality control mechanism and recycles their components to sustain survival in starvation. Cel...

    Eileen White

    Cancer & Metabolism 2014 2:14

    Published on: 11 September 2014

  2. Forum

    Definitions and potential health benefits of the Mediterranean diet: views from experts around the world

    The Mediterranean diet has been linked to a number of health benefits, including reduced mortality risk and lower incidence of cardiovascular disease. Definitions of the Mediterranean diet vary across some set...

    Antonia Trichopoulou, Miguel A Martínez-González, Tammy YN Tong, Nita G Forouhi, Shweta Khandelwal, Dorairaj Prabhakaran, Dariush Mozaffarian and Michel de Lorgeril

    BMC Medicine 2014 12:112

    Published on: 24 July 2014

  3. Research article

    Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial

    Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipid...

    Anna Tresserra-Rimbau, Eric B Rimm, Alexander Medina-Remón, Miguel A Martínez-González, M Carmen López-Sabater, María I Covas, Dolores Corella, Jordi Salas-Salvadó, Enrique Gómez-Gracia, José Lapetra, Fernando Arós, Miquel Fiol, Emili Ros, Lluis Serra-Majem, Xavier Pintó, Miguel A Muñoz…

    BMC Medicine 2014 12:77

    Published on: 13 May 2014

  4. Research article

    Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study

    It is unknown whether individuals at high cardiovascular risk sustain a benefit in cardiovascular disease from increased olive oil consumption. The aim was to assess the association between total olive oil int...

    Marta Guasch-Ferré, Frank B Hu, Miguel A Martínez-González, Montserrat Fitó, Mònica Bulló, Ramon Estruch, Emilio Ros, Dolores Corella, Javier Recondo, Enrique Gómez-Gracia, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Miguel A Muñoz, Xavier Pintó, Rosa M Lamuela-Raventós…

    BMC Medicine 2014 12:78

    Published on: 13 May 2014

  5. Research article

    Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study

    A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influenc...

    Elin Strand, Eva R Pedersen, Gard FT Svingen, Hall Schartum-Hansen, Eirik W Rebnord, Bodil Bjørndal, Reinhard Seifert, Pavol Bohov, Klaus Meyer, J Kalervo Hiltunen, Jan E Nordrehaug, Dennis WT Nilsen, Rolf K Berge and Ottar Nygård

    BMC Medicine 2013 11:216

    Published on: 8 October 2013

  6. Research article

    Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial

    The prevalence of type 2 diabetes (T2D) is increasing worldwide and creating a significant burden on health systems, highlighting the need for the development of innovative therapeutic approaches to overcome i...

    Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Huimin Zhou, Zhaohui Yin, Yana Chen, Ye Zhang, Shanfeng Wang, Jie Shen, Hatim Thaker, Summit Jain, Yunxiang Li, Yalin Diao, Yingjian Chen…

    BMC Medicine 2013 11:160

    Published on: 9 July 2013

  7. Research article

    Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

    The carbon metabolism of the blood stages of Plasmodium falciparum, comprising rapidly dividing asexual stages and non-dividing gametocytes, is thought to be highly streamlined, with glycolysis providing most of ...

    James I MacRae, Matthew WA Dixon, Megan K Dearnley, Hwa H Chua, Jennifer M Chambers, Shannon Kenny, Iveta Bottova, Leann Tilley and Malcolm J McConville

    BMC Biology 2013 11:67

    Published on: 13 June 2013

  8. Commentary

    Processing of meats and cardiovascular risk: time to focus on preservatives

    Dietary guidelines emphasize selecting lean (low-fat) meats to reduce saturated fat and cholesterol, but growing evidence suggests that health effects may relate to other ingredients, such as sodium, heme iron...

    Renata Micha, Georgios Michas, Martin Lajous and Dariush Mozaffarian

    BMC Medicine 2013 11:136

    Published on: 23 May 2013

  9. Review

    LKB1 and AMPK and the cancer-metabolism link - ten years after

    The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an ar...

    D Grahame Hardie and Dario R Alessi

    BMC Biology 2013 11:36

    Published on: 15 April 2013

  10. Research article

    Body mass index and incident coronary heart disease in women: a population-based prospective study

    A high body mass index (BMI) is associated with an increased risk of mortality from coronary heart disease (CHD); however, a low BMI may also be associated with an increased mortality risk. There is limited in...

    Dexter Canoy, Benjamin J Cairns, Angela Balkwill, F Lucy Wright, Jane Green, Gillian Reeves and Valerie Beral

    BMC Medicine 2013 11:87

    Published on: 2 April 2013

  11. Research article

    Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

    Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to e...

    Sabine Rohrmann, Kim Overvad, H Bas Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing…

    BMC Medicine 2013 11:63

    Published on: 7 March 2013

  12. Research article

    Shifting from glucose diagnosis to the new HbA1c diagnosis reduces the capability of the Finnish Diabetes Risk Score (FINDRISC) to screen for glucose abnormalities within a real-life primary healthcare preventive strategy

    To investigate differences in the performance of the Finnish Diabetes Risk Score (FINDRISC) as a screening tool for glucose abnormalities after shifting from glucose-based diagnostic criteria to the proposed n...

    Bernardo Costa, Francisco Barrio, Josep L Piñol, Joan J Cabré, Xavier Mundet, Ramon Sagarra, Jordi Salas-Salvadó and Oriol Solà-Morales

    BMC Medicine 2013 11:45

    Published on: 21 February 2013

  13. Research article

    High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study

    The hypothalamic-pituitary-adrenal (HPA) axis, and in particular cortisol, has been reported to be involved in obesity-associated metabolic disturbances in adults and in selected populations of adolescents. Th...

    Flavia Prodam, Roberta Ricotti, Valentina Agarla, Silvia Parlamento, Giulia Genoni, Caterina Balossini, Gillian Elisabeth Walker, Gianluca Aimaretti, Gianni Bona and Simonetta Bellone

    BMC Medicine 2013 11:44

    Published on: 20 February 2013

  14. Research article

    Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial

    Management of type 2 diabetes with metformin often does not provide adequate glycemic control, thereby necessitating add-on treatment. In a 24-week clinical trial, dapagliflozin, an investigational sodium gluc...

    Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield and James F List

    BMC Medicine 2013 11:43

    Published on: 20 February 2013

    The Erratum to this article has been published in BMC Medicine 2013 11:193

  15. Opinion

    Diet, a new target to prevent depression?

    Research on the role of diet in the prevention of depression is scarce. Some evidence suggests that depression shares common mechanisms with cardiovascular disease.

    Almudena Sanchez-Villegas and Miguel A Martínez-González

    BMC Medicine 2013 11:3

    Published on: 3 January 2013

  16. Research article

    Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue

    Periprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostatic organ towards this fat d...

    Ricardo Ribeiro, Cátia Monteiro, Victoria Catalán, Pingzhao Hu, Virgínia Cunha, Amaia Rodríguez, Javier Gómez-Ambrosi, Avelino Fraga, Paulo Príncipe, Carlos Lobato, Francisco Lobo, António Morais, Vitor Silva, José Sanches-Magalhães, Jorge Oliveira, Francisco Pina…

    BMC Medicine 2012 10:108

    Published on: 25 September 2012

  17. Research article

    Excessive folate synthesis limits lifespan in the C. elegans: E. coliaging model

    Gut microbes influence animal health and thus, are potential targets for interventions that slow aging. Live E. coli provides the nematode worm Caenorhabditis elegans with vital micronutrients, such as folates th...

    Bhupinder Virk, Gonçalo Correia, David P Dixon, Inna Feyst, Jie Jia, Nikolin Oberleitner, Zoe Briggs, Emily Hodge, Robert Edwards, John Ward, David Gems and David Weinkove

    BMC Biology 2012 10:67

    Published on: 31 July 2012

  18. Research article

    Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: results from a randomized clinical trial

    Metabolic syndrome (METS) is an increasingly prevalent but poorly understood clinical condition characterized by insulin resistance, glucose intolerance, dyslipidemia, hypertension, and obesity. Increased oxid...

    Khosrow S Houschyar, Rainer Lüdtke, Gustav J Dobos, Ulrich Kalus, Martina Broecker-Preuss, Thomas Rampp, Benno Brinkhaus and Andreas Michalsen

    BMC Medicine 2012 10:54

    Published on: 30 May 2012

  19. Commentary

    Back to past leeches: repeated phlebotomies and cardiovascular risk

    In patients with metabolic syndrome, body iron overload exacerbates insulin resistance, impairment of glucose metabolism, endothelium dysfunction and coronary artery responses. Conversely, iron depletion is ef...

    Melania Manco and Josè Manuel Fernandez-Real

    BMC Medicine 2012 10:53

    Published on: 30 May 2012

  20. Research article

    Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial

    Endothelial dysfunction has been proposed as the underlying cause of diabetic angiopathy that eventually leads to cardiovascular disease, the major cause of death in diabetes. We recently demonstrated the amel...

    Sakineh Shab-Bidar, Tirang R Neyestani, Abolghassem Djazayery, Mohammad-Reza Eshraghian, Anahita Houshiarrad, A'azam Gharavi, Ali Kalayi, Nastaran Shariatzadeh, Malihe Zahedirad, Niloufar Khalaji and Homa Haidari

    BMC Medicine 2011 9:125

    Published on: 24 November 2011

  21. Review

    Epigenetic regulation of caloric restriction in aging

    The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans. The aging process is frequently...

    Yuanyuan Li, Michael Daniel and Trygve O Tollefsbol

    BMC Medicine 2011 9:98

    Published on: 25 August 2011