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Open Access Debate

When to start antiretroviral therapy: the need for an evidence base during early HIV infection

Jens D Lundgren12*, Abdel G Babiker3, Fred M Gordin4, Álvaro H Borges12 and James D Neaton5

Author Affiliations

1 Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

2 Copenhagen HIV Programme, University of Copenhagen, The Panum Institute/Building 21.1, Blegdamsvej 3B, 2200, Copenhagen, N, Copenhagen, Denmark

3 MRC Clinical Trials Unit, Aviation House, 125 Kingsway, London WC2B 6NH, UK

4 Veterans Affairs Medical Center and George Washington University, 50 Irving St, Washington, DC 20422 202-745-8000, USA

5 Division of Biostatistics, University of Minnesota, A460 Mayo Building, 420 Delaware Street, Minneapolis, MN 55455, USA

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BMC Medicine 2013, 11:148  doi:10.1186/1741-7015-11-148

Published: 14 June 2013

Abstract

Background

Strategies for use of antiretroviral therapy (ART) have traditionally focused on providing treatment to persons who stand to benefit immediately from initiating the therapy. There is global consensus that any HIV+ person with CD4 counts less than 350 cells/μl should initiate ART. However, it remains controversial whether ART is indicated in asymptomatic HIV-infected persons with CD4 counts above 350 cells/μl, or whether it is more advisable to defer initiation until the CD4 count has dropped to 350 cells/μl. The question of when the best time is to initiate ART during early HIV infection has always been vigorously debated. The lack of an evidence base from randomized trials, in conjunction with varying degrees of therapeutic aggressiveness and optimism tempered by the risks of drug resistance and side effects, has resulted in divided expert opinion and inconsistencies among treatment guidelines.

Discussion

On the basis of recent data showing that early ART initiation reduces heterosexual HIV transmission, some countries are considering adopting a strategy of universal treatment of all HIV+ persons irrespective of their CD4 count and whether ART is of benefit to the individual or not, in order to reduce onward HIV transmission. Since ART has been found to be associated with both short-term and long-term toxicity, defining the benefit:risk ratio is the critical missing link in the discussion on earlier use of ART. For early ART initiation to be justified, this ratio must favor benefit over risk. An unfavorable ratio would argue against using early ART.

Summary

There is currently no evidence from randomized controlled trials to suggest that a strategy of initiating ART when the CD4 count is above 350 cells/μl (versus deferring initiation to around 350 cells/μl) results in benefit to the HIV+ person and data from observational studies are inconsistent. Large, clinical endpoint-driven randomized studies to determine the individual health benefits versus risks of earlier ART initiation are sorely needed.

The counter-argument to this debate topic can be freely accessed here: http://www.biomedcentral.com/1741-7015/11/147 webcite.

Keywords:
Antiretroviral therapy; Benefit; CD4 count; Drug toxicity; HIV; Risk ratio; Treatment as prevention