HIV thirty years on
Collection published: 21 May 2013
Last updated: 3 September 2013
It has been thirty years since human immunodeficiency virus (HIV) was first identified as the cause of acquired immunodeficiency syndrome (AIDS) , a landmark discovery that has led to tremendous progress in understanding and combating infection by this life-threatening retrovirus. The most notable achievement during this time has been the development of antiretroviral therapies that substantially improve the quality and length of life in infected individuals. Nevertheless, to date neither a complete cure nor a protective vaccine have been found, and new infections continue to occur at a rate of 6850 people per day.
In this cross-journal series, Retrovirology, BMC Medicine and BMC Biology take stock of where we are now, with a collection of articles that discuss different aspects of HIV infection, the progress made towards eradicating the virus, and the challenges of fundamental science and clinical management that remain. Selected research articles will be included in addition to invited reviews and comment.
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Modeling the within-host dynamics of HIV infection
Alan S Perelson, Ruy M Ribeiro BMC Biology 2013, 11:96 (3 September 2013)
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Alan Perelson and Ruy Ribeiro explain how differential equations that model the dynamics of HIV replication in its human host have led to important quantitative insights into the biology of HIV infection. |
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Translational HIV-1 research: from routine diagnostics to new virology insights in Amsterdam, the Netherlands during 1983-2013
Antoinette C van der Kuyl, Margreet Bakker, Suzanne Jurriaans, Nicole KT Back, Alexander O Pasternak, Marion Cornelissen, Ben Berkhout Retrovirology 2013, 10:93 (28 August 2013)
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Challenges and opportunities for oral pre-exposure prophylaxis in the prevention of HIV infection: where are we in Europe?
Jean-Michel Molina, Claire Pintado, Caroline Gatey, Diane Ponscarme, Pierre Charbonneau, Benedicte Loze, Willy Rozenbaum, Constance Delaugerre BMC Medicine 2013, 11:186 (23 August 2013)
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Pre-exposure prophylaxis (PrEP) with antiretroviral therapy is thought to help prevent HIV transmission; Jean-Michel Molina and colleagues discuss the controversy surrounding PrEP in Europe, and highlight the issues that need to be addressed. |
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Evolving uses of oral reverse transcriptase inhibitors in the HIV-1 epidemic: from treatment to prevention
Ravindra K Gupta, David A M C Van de Vijver, Sheetal Manicklal, Mark A Wainberg Retrovirology 2013, 10:82 (31 July 2013)
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Development of prophylactic vaccines against HIV-1
Torben Schiffner, Quentin J Sattentau, Lucy Dorrell Retrovirology 2013, 10:72 (17 July 2013)
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Video Q&A: Rapid urine LAM test for HIV-associated TB - potential to reduce deaths? An interview with Stephen Lawn
Stephen D Lawn BMC Medicine 2013, 11:158 (4 July 2013)
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In this Q&A, we talk to Stephen Lawn about the point-of-care LAM test for HIV-associated TB, which could save lives by improving rapid diagnosis and treatment. |
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HIV-1 transcription and latency: an update
Carine Van Lint, Sophie Bouchat, Alessandro Marcello Retrovirology 2013, 10:67 (26 June 2013)
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When to start antiretroviral therapy: the need for an evidence base during early HIV infection
Jens D Lundgren, Abdel G Babiker, Fred M Gordin, Álvaro H Borges, James D Neaton BMC Medicine 2013, 11:148 (14 June 2013)
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Jens Lundgren and colleagues argue for a more cautious approach to starting antiretroviral therapy, highlighting that there is no evidence from randomized trials to suggest the benefits of starting therapy early outweigh the potential harms. |
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When to start antiretroviral therapy: as soon as possible
Ricardo A Franco, Michael S Saag BMC Medicine 2013, 11:147 (14 June 2013)
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Ricardo Franco and Michael Saag discuss the benefits of starting HIV therapy early, arguing that treatment should be given as soon as possible to reduce viral replication, prevent transmission and avoid the problems associated with inflammation. |
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The frantic play of the concealed HIV envelope cytoplasmic tail
Eveline Santos da Silva, Martin Mulinge, Danielle Perez Bercoff Retrovirology 2013, 10:54 (24 May 2013)
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The HIV-1 pandemic: does the selective sweep in chimpanzees mirror humankind’s future?
Natasja G de Groot, Ronald E Bontrop Retrovirology 2013, 10:53 (24 May 2013)
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In pursuit of an HIV vaccine: an interview with Andrew McMichael
Andrew J McMichael BMC Biology 2013, 11:60 (21 May 2013)
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Can the immune system be induced to protect itself against HIV infection? Andrew McMichael gives his perspective in an interview, explaining the challenges faced in making a vaccine and why he remains optimistic about the potential of eliciting strong T cell responses for controlling the virus. |
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Thirty years on: HIV receptor gymnastics and the prevention of infection
Robin A Weiss BMC Biology 2013, 11:57 (21 May 2013)
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Robin Weiss, in an article to mark the 30th anniversary of the discovery of the human immunodeficiency virus (HIV), reviews the complex interactions of the virus with the specialized surface molecules by which it gains entry into cells, and how this has led to drugs that block it. |
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Molecular signatures of T-cell inhibition in HIV-1 infection
Marie Larsson, Esaki M Shankar, Karlhans F Che, Alireza Saeidi, Rada Ellegård, Muttiah Barathan, Vijayakumar Velu, Adeeba Kamarulzaman Retrovirology 2013, 10:31 (20 March 2013)
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