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World AIDS Day 2013

1st December every year is World AIDS Day, and it is an opportunity not only to raise awareness of the disease, but to highlight the progress made by scientists and clinicians around the world to understand and find ways to cure the disease.

Over 30 years have passed since the discovery of HIV/AIDS, and in that time, there have been strong advancements in our understanding of HIV and AIDS and the development of potential therapeutics.

The articles below showcase the breadth and high caliber of the AIDS and HIV research published in our open access journals AIDS Research & Therapy, BMC Infectious Diseases, Retrovirology and Virology Journal.

  1. Review

    A cure for AIDS: a matter of timing?

    Despite the huge clinical success of antiretroviral therapy, several factors such as side effects, requirement of life-long adherence, high cost, incomplete access to therapies and development of drug resistan...

    Iart Luca Shytaj and Andrea Savarino

    Retrovirology 2013 10:145

    Published on: 22 November 2013

  2. Research article

    Local phylogenetic analysis identifies distinct trends in transmitted HIV drug resistance: implications for public health interventions

    HIV transmitted drug resistance (TDR) surveillance is usually conducted by sampling from a large population. However, overall TDR prevalence results may be inaccurate for many individual clinical setting. We a...

    James I Brooks, Harrison Niznick, Marianna Ofner, Harriet Merks and Jonathan B Angel

    BMC Infectious Diseases 2013 13:509

    Published on: 30 October 2013

  3. Research article

    HIV-associated tuberculosis: relationship between disease severity and the sensitivity of new sputum-based and urine-based diagnostic assays

    Reducing mortality from HIV-associated tuberculosis (TB) requires diagnostic tools that are rapid and have high sensitivity among patients with poor prognosis. We determined the relationship between disease se...

    Stephen D Lawn, Andrew D Kerkhoff, Monica Vogt and Robin Wood

    BMC Medicine 2013 11:231

    Published on: 29 October 2013

  4. Research article

    Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana

    Antiretroviral therapy (ART) scale-up in resource-limited countries, with limited capacity for CD4 and HIV viral load monitoring, presents a unique challenge. We determined the effectiveness of first-line ART ...

    Oliver Barry, Jonathan Powell, Lorna Renner, Evelyn Y Bonney, Meghan Prin, William Ampofo, Jonas Kusah, Bamenla Goka, Kwamena WC Sagoe, Veronika Shabanova and Elijah Paintsil

    BMC Infectious Diseases 2013 13:476

    Published on: 13 October 2013

  5. Research article

    The potential impact of routine testing of individuals with HIV indicator diseases in order to prevent late HIV diagnosis

    The aim of our work was to evaluate the potential impact of the European policy of testing for HIV all individuals presenting with an indicator disease, to prevent late diagnosis of HIV. We report on a retrosp...

    Paola Scognamiglio, Giacomina Chiaradia, Gabriella De Carli, Massimo Giuliani, Claudio Maria Mastroianni, Stefano Aviani Barbacci, Anna Rita Buonomini, Susanna Grisetti, Alessandro Sampaolesi, Angela Corpolongo, Nicoletta Orchi, Vincenzo Puro, Giuseppe Ippolito and Enrico Girardi

    BMC Infectious Diseases 2013 13:473

    Published on: 10 October 2013

  6. Research

    Risk factors of chronic hepatitis in antiretroviral-treated HIV infection, without hepatitis B or C viral infection

    Increasing rates of non-AIDS defining illnesses, and in particular liver diseases, have been found after the initiation of highly active antiretroviral therapy. However, there is little evidence concerning the...

    Thep Chalermchai, Narin Hiransuthikul, Pisit Tangkijvanich, Suteeraporn Pinyakorn, Anchalee Avihingsanon and Jintanat Ananworanich

    AIDS Research and Therapy 2013 10:21

    Published on: 26 July 2013

  7. Research

    Virologic and immunologic outcome of HAART in Human Immunodeficiency Virus (HIV)-1 infected patients with and without tuberculosis (TB) and latent TB infection (LTBI) in Addis Ababa, Ethiopia

    HIV/TB coinfection remains a major challenge even after the initiation of HAART. Little is known about Mycobacterium tuberculosis (Mtb) specific immune restoration in relation to immunologic and virologic outcome...

    Desta Kassa, Gebremedhin Gebremichael, Yodit Alemayehu, Dawit Wolday, Tsehaynesh Messele and Debbie van Baarle

    AIDS Research and Therapy 2013 10:18

    Published on: 10 July 2013

  8. Research article

    Knowledge, attitudes, and behaviors regarding HIV among first time attenders of voluntary counseling and testing services in Italy

    This study assess knowledge, attitudes, and practices regarding Human Immunodeficiency Virus (HIV) testing and counseling services and the predictor characteristics of these outcomes among individuals who pres...

    Gabriella Di Giuseppe, Alessandra Sessa, Silvana Mollo, Natascia Corbisiero and Italo F Angelillo

    BMC Infectious Diseases 2013 13:277

    Published on: 19 June 2013

  9. Debate

    When to start antiretroviral therapy: as soon as possible

    The debate regarding ‘When to Start’ antiretroviral therapy has raged since the introduction of zidovudine in 1987. Based on the entry criteria for the original Burroughs Wellcome 002 study, the field has been...

    Ricardo A Franco and Michael S Saag

    BMC Medicine 2013 11:147

    Published on: 14 June 2013

  10. Research article

    Effect of nutritional factors on adherence to antiretroviral therapy among HIV-infected adults: a case control study in Northern Ethiopia

    Adherence to antiretroviral treatment is critical for suppression of viral replication, reduced destruction of CD4 cells, prevention of viral resistance, promotion of immune reconstitution and slowed disease prog...

    Negassie Berhe, Desalegn Tegabu and Mekuriaw Alemayehu

    BMC Infectious Diseases 2013 13:233

    Published on: 23 May 2013

  11. Research

    Self-care practices and experiences of people living with HIV not receiving antiretroviral therapy in an urban community of Lusaka, Zambia: implications for HIV treatment programmes

    Despite the increasingly wider availability of antiretroviral therapy (ART), some people living with HIV (PLHIV) and eligible for treatment have opted to adopt self-care practices thereby risking early AIDS-re...

    Maurice Musheke, Virginia Bond and Sonja Merten

    AIDS Research and Therapy 2013 10:12

    Published on: 15 May 2013

  12. Research

    A monoclonal antibody against lymphocyte function-associated antigen-1 decreases HIV-1 replication by inducing the secretion of an antiviral soluble factor

    Lymphocyte Function-Associated Antigen-1 (LFA-1) likely plays a role in the pathogenesis of against HIV-1 and is known to facilitate cell-to-cell transmission of the virus. A monoclonal antibody specific for L...

    Jenna Rychert, Lindsay Jones, Graham McGrath, Sue Bazner and Eric S Rosenberg

    Virology Journal 2013 10:120

    Published on: 18 April 2013

  13. Research

    Synthetic immunotherapy induces HIV virus specific Th1 cytotoxic response and death of an HIV-1 infected human cell line through classic complement activation

    This manuscript describes the development of a novel synthetic immunotherapy (HIV-v) composed of four multi-epitope polypeptides targeting conserved regions in the Nef, Rev, Vif and Vpr viral proteins. Immunog...

    Olga Pleguezuelos, Gregory A Stoloff and Wilson Caparrós-Wanderley

    Virology Journal 2013 10:107

    Published on: 4 April 2013