Figure 1.

CD133+CXCR4+ cancer cell content is higher in hepatic metastasis than in human primary colorectal tumors. (A) Specimens were digested, stained for CD133 and analyzed by flow cytometry to detect the CD133+ subpopulation in primary and metastatic colorectal cancer as well as their corresponding normal tissues. A representative image is provided in the left panel. Quantification of flow cytometry data is presented in the right panel. (B) To assess the CD133+CXCR4+ subpopulation in human specimens, primary and metastatic colorectal tumors were harvested, digested and double-stained for CD133 and CXCR4, then analyzed by flow cytometry. A representative image is provided in the left panel. Quantification of flow cytometry data is presented in the right panel (n = 9 analyzed patients).

Zhang et al. BMC Medicine 2012 10:85   doi:10.1186/1741-7015-10-85
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