- Hans-Joachim Anders, Ludwig-Maximilians-University
- Adrian Covic, Parhon University Hospital
- Michelle Estrella, Johns Hopkins School of Medicine
- Jerome Harambat, Hôpital des Enfants CHU de Bordeaux
- Bernard Jaar, Johns Hopkins Medical Institutions
- William Oetting, University of Minnesota
- Giorgina Piccoli, University of Torino
- Donald S Silverberg, Tel Aviv Medical Center
- Robert Unwin, University College London
- Hayley Henderson, BioMed Central
Analysing the properties of the major cell types of the glomerulus in Cd2ap mutant mouse models of focal segmental glomerulosclerosis identified activated and repressed pathways, and responsible genes, thereby delivering a deeper molecular understanding of this genetic disease.
Annual hospital care costs associated with CKD stage and cardiovascular disease in the UK, reports that major vascular events, and vascular and non-vascular deaths, are key determinants of hospital care costs in CKD, in addition to the need for renal replacement therapy.
Elevated serum Cystatin C (Cyst-C) is independently associated with future risk of sepsis, and this association persists after adjustment for markers of kidney disease and systemic inflammation, indicating that Cyst-C may play a role in sepsis risk prediction and reduction.
Investigations into global renal registries revealed a lack of available data, particularly in emerging economies; however, more effective policy and patient care decisions could be made through multistakeholder collaborations helping develop, or enhance data collection for new and existing registries.
Shuchi Anand et al. discuss how recent research has improved our understanding of (AKI) in low-resource settings, and additional well-designed, high quality epidemiological studies are needed to help inform the design of AKI prevention and treatment programs in these settings.
ATP_CD4 may be a potential marker for predicting renal prognosis in sepsis-associated AKI, with lower concentrations being linked to a higher chance for complete renal recovery; however further studies are required to specify this marker’s role in AKI risk prediction.
David Gustafsson and Robert Unwin look into uric acid metabolism and review the current literature on the pathophysiology of hyperuricaemia, discussing its possible relationship to cardiovascular disease, morbidity and mortality and emerging treatment options.BMC Nephrology 2013, 14:164
BMC Nephrology 2015, 16:68
BMC Nephrology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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Section Editor's profile
William Oetting is currently a Professor in the Departments of Experimental and Clinical Pharmacology in the College of Pharmacy and Genetics, Cell Biology and Development at in the MedicalSchool at the University of Minnesota. Professor Oetting's research focuses on the genetic analysis of common diseases. In particular, the effects of genetic variation on kidney allograft health and survival for kidney transplant recipients. As genetic variants associated with kidney function and/or disease are identified, they will become candidates for other diseases which include the kidney. He is also interested in identifying proteomic and metabolomics markers associated with kidney health after transplantation.
"I am pleased to have been involved with BMC Nephrology, first as an Associate Editor and now as Section Editor for the Genetics section. I have been impressed with the journal's high editorial standards, and rapidity of the peer review and publication process. Moreover, I strongly believe in the value of BMC Nephrology's open access policy, which makes new knowledge available to the global nephrology community, irrespective of institutional affiliation or financial means.
The genetics section of BMC Nephrology will provide a forum for investigators who are interested in genetic variation and their impact on kidney development, function, disease and response to therapy. Kidney disease is the ninth leading cause of death in the United States. The variability between individuals with kidney disease on overall health (e.g. glomerular diseases), or on kidney health (e.g. type 2 diabetes), shows why understanding the genetics of kidney disease is important. I am looking forward to the many contributions associated with the genetics of kidney health and disease that will be published in BMC Nephrology."