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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Danielle Burgess PhD
Welcome to BMC Bioinformatics published by BioMed Central
BMC Bioinformatics is an open access journal publishing original peer-reviewed research articles in all aspects of the development, testing and novel application of computational and statistical methods for the modeling and analysis of all kinds of biological data, as well as other areas of computational biology.
BMC Bioinformatics (ISSN 1471-2105) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, EMBASE, Scopus, Thomson Reuters (ISI) and Google Scholar.
BMC Bioinformatics 2010, 11 :68
A new method for clustering time-course microarray gene expression datasets, using a Granger causality approach to test the temporal relationships between genes, provides a promising way to group functionally related genes.
BMC Bioinformatics 2009, 10 :447
Next generation sequencing technologies have resulted in an explosion of transcriptome projects in non-model organisms and est2assembly is a useful tool for the assembly, annotation, analysis and visualization of such data.
BMC Bioinformatics 2009, 10 :421
With the advent of more complete genomes BLAST has been re-written to include a new set of command line searches and a new modular structure, giving substantial speed improvements for long queries and an improved user interface.
BMC Bioinformatics 2009, 10 :402
Double filtering using fold change and t test to find differentially expressed genes loses power due to differing assumptions about variance, whereas combining Bayesian mixture models with SAM approaches the performance of the theoretically best likelihood ratio test statistic.
BMC Bioinformatics 2009, 10 :S6
Scratchpads, a new social networking tool for natural history researchers and enthusiasts, links information from disparate sources, encourages data sharing, and promotes the ultimate goal of describing and synthesising all facets of the diversity of life.
Volume 11 Suppl 1
Research
Bangalore, India. 18-21 January 2010
Volume 10 Suppl 15
Proceedings
Singapore. 7-11 September 2009
Volume 10 Suppl 14
Research
more info ]
Software
Dynamic probe selection for studying microbial transcriptome with high-density genomic tiling microarrays Hedda Hovik, Tsute Chen BMC Bioinformatics 2010, 11 :82 (9 [Abstract ] [Provisional PDF ]
Research article
An effective approach for identification of in vivo protein-DNA binding sites from paired-end ChIP-Seq data Congmao Wang, Jie Xu, Dasheng Zhang, Zoe A Wilson, Dabing Zhang BMC Bioinformatics 2010, 11 :81 (9 [Abstract ] [Provisional PDF ]
Research article
Parameters for accurate genome alignment Martin C Frith, Michiaki Hamada, Paul Horton BMC Bioinformatics 2010, 11 :80 (9 [Abstract ] [Provisional PDF ]
Research article
Using simple artificial intelligence methods for predicting
amyloidogenesis in antibodies Maria Pamela C David, Gisela P Concepcion, Eduardo A Padlan BMC Bioinformatics 2010, 11 :79 (8 [Abstract ] [Provisional PDF ]
Methodology article
Testing the additional predictive value of high-dimensional
molecular data Anne-Laure Boulesteix, Torsten Hothorn BMC Bioinformatics 2010, 11 :78 (8 [Abstract ] [Provisional PDF ]
Methodology article
A random effect multiplicative heteroscedastic model for bacterial
growth Ricardo Cao, Mario Francisco-Fernandez, Emiliano J Quinto BMC Bioinformatics 2010, 11 :77 (8 [Abstract ] [Provisional PDF ]
Research article
Extracting consistent knowledge from highly inconsistent cancer gene data sources Xue Gong, Ruihong Wu, Yuannv Zhang, Wenyuan Zhao, Lixin Cheng, Yunyan Gu, Lin Zhang, Jing Wang, Jing Zhu, Zheng Guo BMC Bioinformatics 2010, 11 :76 (5 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Mining protein loops using a structural alphabet and
statistical exceptionality Leslie Regad, Juliette Martin, Gregory Nuel, Anne-claude Camproux BMC Bioinformatics 2010, 11 :75 (4 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
CNV Workshop: an integrated platform for high-throughput copy number variation discovery and clinical diagnostics Xiaowu Gai, Juan C Perin, Kevin Murphy, Ryan O'Hara, Monica D'arcy, Adam Wenocur, Hongbo M Xie, Eric F Rappaport, Tamim H Shaikh, Peter S White BMC Bioinformatics 2010, 11 :74 (4 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
BABAR: an R package to simplify the normalisation of common reference design microarray-based transcriptomic datasets Mark J Alston, John Seers, Jay CD Hinton, Sacha Lucchini BMC Bioinformatics 2010, 11 :73 (3 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
2X genomes - depth does matter Michel C Milinkovitch, Raphael Helaers, Eric Depiereux, Athanasia C Tzika, Toni Gabaldon Genome Biology 2010, 11 :R16 (9 [Abstract ] [Provisional PDF ]
Research article
Computational prediction and experimental validation of evolutionarily conserved microRNA target genes in bilaterian animals Kahori Takane, Kosuke Fujishima, Yuka Watanabe, Asako Sato, Nobuto Saito, Masaru Tomita, Akio Kanai BMC Genomics 2010, 11 :101 (9 [Abstract ] [Provisional PDF ]
Research article
Variability of gene expression profiles in human blood and lymphoblastoid cell lines Josine L Min, Amy Barrett, Tim Watts, Fredrik H Pettersson, Helen E Lockstone, Cecilia M Lindgren, Jennifer M Taylor, Maxine Allen, Krina T Zondervan, Mark I McCarthy BMC Genomics 2010, 11 :96 (8 [Abstract ] [Provisional PDF ]
Research article
Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications Chi Nam Ignatius Pang, Elisabeth Gasteiger, Marc R Wilkins BMC Genomics 2010, 11 :92 (5 [Abstract ] [Provisional PDF ]
Method
Gene ontology analysis for RNA-seq: accounting for selection bias Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack Genome Biology 2010, 11 :R14 (4 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software article
Jane: A new tool for the cophylogeny reconstruction problem Chris Conow, Daniel Fielder, Yaniv Ovadia, Ran Libeskind-Hadas Algorithms for Molecular Biology 2010, 5 :16 (3 [Abstract ] [Provisional PDF ]
Method
Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging Kristen Fortney, Max Kotlyar, Igor Jurisica Genome Biology 2010, 11 :R13 (3 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Genomic and small RNA sequencing of Miscanthus x giganteus shows the utility of sorghum as a reference genome sequence for Andropogoneae grasses Kankshita Swaminathan, Magdy Alabady, Kranthi Varala, Emanuele De Paoli, Isaac Ho, Dan S Rokhsar, Aru K Arumuganathan, Ray Ming, Pamela J Green, Blake C Meyers, Stephen P Moose, Matthew E Hudson Genome Biology 2010, 11 :R12 (3 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
A general co-expression network-based approach to gene expression analysis: comparison and applications Jianhua Ruan, Angela K Dean, Weixiong Zhang BMC Systems Biology 2010, 4 :8 (2 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Systematic overrepresentation of DNA termini and underrepresentation of subterminal regions among sequencing templates prepared from hydrodynamically sheared linear DNA molecules Sherri L Schwartz, Mark L Farman BMC Genomics 2010, 11 :87 (2 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
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