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	1. 738 Accesses	Technical advance Validation of an LC-MS/MS method to determine five immunosuppressants with deuterated internal standards including MPA Armin Buchwald, Karl Winkler, Thomas Epting BMC Clinical Pharmacology 2012, 12:2 (11 January 2012) Abstract \| Full text \| PDF \| PubMed
	2. 719 Accesses	Research article Finasteride induced depression: a prospective study Babak Rahimi-Ardabili, Ramin Pourandarjani, Peiman Habibollahi, Amir Mualeki BMC Clinical Pharmacology 2006, 6:7 (7 October 2006) Abstract \| Full text \| PDF \| PubMed \| 1 comment
	3. 698 Accesses	Research article Effects of simvastatin 40 mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people MRC/BHF Heart Protection Study Collaborative Group BMC Clinical Pharmacology 2009, 9:6 (31 March 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Simvastatin treatment for patients at high risk of cardiovascular events or with diabetes results in only a minor increase in the risk of myopathy and hepatobiliary diseases over 5 years of use.
	4. 671 Accesses	Case report Intrathecal baclofen withdrawal syndrome- a life-threatening complication of baclofen pump: A case report Imran Mohammed, Asif Hussain BMC Clinical Pharmacology 2004, 4:6 (9 August 2004) Abstract \| Full text \| PDF \| PubMed
	5. 572 Accesses	Research article Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family Megan Morse, Haiyan Sun, Elizabeth Tran, Robert Levenson, Ye Fang BMC Pharmacology and Toxicology 2013, 14:17 (12 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A label-free integrative pharmacology on-target (iPOT) approach systematically surveys a library of opioid ligands against the opioid receptor family and effectively sorts them into distinct clusters based on their binding and functional selectivity.
	6. 568 Accesses	Research article Bioavailability of ibuprofen following oral administration of standard ibuprofen, sodium ibuprofen or ibuprofen acid incorporating poloxamer in healthy volunteers Peter M Dewland, Sandie Reader, Phillip Berry BMC Clinical Pharmacology 2009, 9:19 (4 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The time to maximum blood concentration of ibuprofen is cut from 90 minutes to just 35 minutes if ibuprofen sodium dihydrate is taken rather than the standard formulation, but adding poloxamer makes no significant difference to bioavailability.
	7. 488 Accesses	Research article Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus Elizabeth K Hussey, Anita Kapur, Robin O¿Connor-Semmes, Wenli Tao, Bryan Rafferty, Joseph W Polli, Charles D James, Robert L Dobbins BMC Pharmacology and Toxicology 2013, 14:25 (30 April 2013) Abstract \| Provisional PDF \| PubMed
	8. 475 Accesses	Research article Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A - Medical results James B Adams, Matthew Baral, Elizabeth Geis, Jessica Mitchell, Julie Ingram, Andrea Hensley, Irene Zappia, Sanford Newmark, Eva Gehn, Robert A Rubin, Ken Mitchell, Jeff Bradstreet, Jane El-Dahr BMC Clinical Pharmacology 2009, 9:16 (23 October 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	9. 446 Accesses	Research article Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans Maxwell CK Leung, John P Rooney, Ian T Ryde, Autumn J Bernal, Amanda S Bess, Tracey L Crocker, Alex Q Ji, Joel N Meyer BMC Pharmacology and Toxicology 2013, 14:9 (4 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exposure of developing Caenorhabditis elegans to ultraviolet C radiation results in decreased ATP levels and oxygen consumption in later life, suggesting that early life contact with mitochondrial genotoxicants may lead to time-delayed mitochondrial dysfunction.
	10. 443 Accesses	Case report Rifampicin-warfarin interaction leading to macroscopic hematuria: a case report and review of the literature Maria AP Martins, Adriano MM Reis, Mariana F Sales, Vandack Nobre, Daniel D Ribeiro, Manoel OC Rocha, Antônio LP Ribeiro BMC Pharmacology and Toxicology 2013, 14:27 (4 May 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	11. 420 Accesses	Review Role of astrocytes in manganese mediated neurotoxicity Marta Sidoryk-Wegrzynowicz, Michael Aschner BMC Pharmacology and Toxicology 2013, 14:23 (18 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	12. 420 Accesses	Research article Pharmaceutical quality of seven generic Levodopa/Benserazide products compared with original Madopar® / Prolopa® Urs E Gasser, Anton Fischer, Jan P Timmermans, Isabelle Arnet BMC Pharmacology and Toxicology 2013, 14:24 (23 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	13. 407 Accesses	Research article Application of microbiological assay to determine pharmaceutical equivalence of generic intravenous antibiotics Andres F Zuluaga, Maria Agudelo, Carlos A Rodriguez, Omar Vesga BMC Clinical Pharmacology 2009, 9:1 (16 January 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Pharmaceutical equivalence of generic intravenous antibiotics can be assessed prior to their clinical use by providing information about potency and efficacy using a new microbiological assay with reference bacteria
	14. 406 Accesses	Research article Hit identification of IKKβ natural product inhibitor Chung-Hang Leung, Daniel Shiu-Hin Chan, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma BMC Pharmacology and Toxicology 2013, 14:3 (7 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A benzoic acid derivative, identified by high-throughput virtual screening and molecular modeling, is capable of inhibiting IKKβ phosphorylation activity in vitro, and blocking IκBα protein degradation together with subsequent NF-κB activation in human cells.
	15. 401 Accesses	Review A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study Suzanne Dunne, Bill Shannon, Colum Dunne, Walter Cullen BMC Pharmacology and Toxicology 2013, 14:1 (5 January 2013) Abstract \| Full text \| PDF \| PubMed
	16. 387 Accesses	Reviewer acknowledgement Annual acknowledgement of manuscript reviewers Christopher Morrey BMC Pharmacology and Toxicology 2013, 14:21 (29 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	17. 367 Accesses	Research article First human dose-escalation study with remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), in healthy subjects and in subjects with type 2 diabetes mellitus Anita Kapur, Robin O¿Connor-Semmes, Elizabeth K Hussey, Robert L Dobbins, Wenli Tao, Marcus Hompesch, Glenn A Smith, Joseph W Polli, Charles D James Jr, Imao Mikoshiba, Derek J Nunez BMC Pharmacology and Toxicology 2013, 14:26 (13 May 2013) Abstract \| Provisional PDF \| PubMed
	18. 357 Accesses	Research article The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol Trevor Tanner, Sue Aspley, Andrew Munn, Tracy Thomas BMC Clinical Pharmacology 2010, 10:10 (5 July 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Paracetemol is absorbed significantly faster when taken in a combination dose with ibuprofen compared to when taken in isolation, with greater blood plasma concentrations of both being reached earlier, offering potentially enhanced pain relief.
	19. 333 Accesses	Research article Efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of moderate/severe chronic non-malignant pain: results of a prospectively designed pooled analysis of two randomised, double-blind clinical trials Oliver Löwenstein, Petra Leyendecker, Eberhard A Lux, Mark Blagden, Karen H Simpson, Michael Hopp, Björn Bosse, Karen Reimer BMC Clinical Pharmacology 2010, 10:12 (29 September 2010) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Chronic non-malignant pain sufferers with opiod-induced constipation have improved bowel function without compromising analgesic efficacy when taking a combination of oxycodone and naloxone pain relief, compared to patients taking oxycodone on its own.
	20. 331 Accesses	Research article Sodium pentosan polysulfate resulted in cartilage improvement in knee osteoarthritis - An open clinical trial- Kenji Kumagai, Susumu Shirabe, Noriaki Miyata, Masakazu Murata, Atsushi Yamauchi, Yasuhumi Kataoka, Masami Niwa BMC Clinical Pharmacology 2010, 10:7 (28 March 2010) Abstract \| Full text \| PDF \| PubMed
	21. 325 Accesses	Debate Promiscuous drugs compared to selective drugs (promiscuity can be a virtue) Simon K Mencher, Long G Wang BMC Clinical Pharmacology 2005, 5:3 (26 April 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Truly selective drugs may be less desirable than more 'promiscuous' drugs which correct the imbalance of several molecules involved in a disease process; this viewpoint has implications for current research trends focused on drug selectivity.
	22. 325 Accesses	Research article Adherence to medication for the treatment of psychosis: rates and risk factors in an Ethiopian population Menna Alene, Michael D Wiese, Mulugeta T Angamo, Beata V Bajorek, Elias A Yesuf, Nasir Wabe BMC Clinical Pharmacology 2012, 12:10 (18 June 2012) Abstract \| Full text \| PDF \| PubMed
	23. 288 Accesses	Research article Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects Howard A Smithline, Michael Donnino, David J Greenblatt BMC Clinical Pharmacology 2012, 12:4 (4 February 2012) Abstract \| Full text \| PDF \| PubMed
	24. 286 Accesses	Research article The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis Farshad Kajbaf, Jean-Daniel Lalau BMC Pharmacology and Toxicology 2013, 14:22 (12 April 2013) Abstract \| Full text \| PDF \| ePUB \| PubMed
	25. 278 Accesses	Research article Constipation and diarrhoea - common adverse drug reactions? A cross sectional study in the general population Gunvor S Fosnes, Stian Lydersen, Per G Farup BMC Clinical Pharmacology 2011, 11:2 (18 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary The use of drugs is significantly associated with an increased prevalence of constipation and diarrhea which are often reported as adverse reactions to medication, suggesting changes in drug regimens should be considered for subjects with these disorders.