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Reporting randomised clinical trials of analgesics after traumatic or orthopaedic surgery is inadequate: a systematic review
Eva Montané, Antoni Vallano, Xavier Vidal, Cristina Aguilera, Joan-Ramon Laporte BMC Clinical Pharmacology 2010, 10:2 (12 January 2010)
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Quantitative relationship between the octanol/water partition coefficient and the diffusion limitation of the exchange between adipose and blood
David G Levitt BMC Clinical Pharmacology 2010, 10:1 (7 January 2010)
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Editor’s summary
The limited diffusion of highly fat soluble persistent organic chemicals between adipose tissue and blood can be explained because as the blood/water partition coefficient increases the adipose perfusion rate decreases.
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Bioavailability of ibuprofen following oral administration of standard ibuprofen, sodium ibuprofen or ibuprofen acid incorporating poloxamer in healthy volunteers
Peter M Dewland, Sandie Reader, Phillip Berry BMC Clinical Pharmacology 2009, 9:19 (4 December 2009)
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Editor’s summary
The time to maximum blood concentration of ibuprofen is cut from 90 minutes to just 35 minutes if ibuprofen sodium dihydrate is taken rather than the standard formulation, but adding poloxamer makes no significant difference to bioavailability.
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In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes
Leonid Gaidukov, Dganit Bar, Shiri Yacobson, Esmira Naftali, Olga Kaufman, Rinat Tabakman, Dan S Tawfik, Etgar Levy-Nissenbaum BMC Clinical Pharmacology 2009, 9:18 (17 November 2009)
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Editor’s summary
Recombinant and high-density lipoprotein complexed forms of serum paraoxonase are stable, do not cause toxic effects and show efficacy against organophosphate poisoning in mice, so have the potential to treat organophosphate toxicity and atherosclerosis in humans.
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Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part B - Behavioral results
James B Adams, Matthew Baral, Elizabeth Geis, Jessica Mitchell, Julie Ingram, Andrea Hensley, Irene Zappia, Sanford Newmark, Eva Gehn, Robert A Rubin, Ken Mitchell, Jeff Bradstreet, Jane El-Dahr BMC Clinical Pharmacology 2009, 9:17 (23 October 2009)
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Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A - Medical results
James B Adams, Matthew Baral, Elizabeth Geis, Jessica Mitchell, Julie Ingram, Andrea Hensley, Irene Zappia, Sanford Newmark, Eva Gehn, Robert A Rubin, Ken Mitchell, Jeff Bradstreet, Jane El-Dahr BMC Clinical Pharmacology 2009, 9:16 (23 October 2009)
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Evaluation of risk factor management of patients treated on an internal nephrology ward: a pilot study
Gunar Stemer, Sonja Zehetmayer, Rosa Lemmens-Gruber BMC Clinical Pharmacology 2009, 9:15 (6 September 2009)
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Perceptions of doctors to adverse drug reaction reporting in a teaching hospital in Lagos, Nigeria
Kazeem A Oshikoya, Jacob O Awobusuyi BMC Clinical Pharmacology 2009, 9:14 (11 August 2009)
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Editor’s summary
Knowledge of adverse drug reactions and the Yellow Card reporting scheme is inadequate among doctors at a teaching hospital in Lagos, Nigeria, and education and training were recognised as the best ways of improving reporting.
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A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion
Debra S Harris, Thomas Everhart, Peyton Jacob, Emil Lin, John E Mendelson, Reese T Jones BMC Clinical Pharmacology 2009, 9:13 (1 August 2009)
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Effect of buspirone on thermal sensory and pain thresholds in human volunteers
Goran Pavlaković, Julija Tigges, Thomas A Crozier BMC Clinical Pharmacology 2009, 9:12 (29 May 2009)
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Dispensed drugs and multiple medications in the Swedish population: an individual-based register study
Bo Hovstadius, Bengt Åstrand, Göran Petersson BMC Clinical Pharmacology 2009, 9:11 (27 May 2009)
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Bioequivalence of HX575 (recombinant human epoetin alfa) and a comparator epoetin alfa after multiple intravenous administrations: an open-label randomised controlled trial
Fritz Sörgel, Ursula Thyroff-Friesinger, Andrea Vetter, Bernhard Vens-Cappell, Martina Kinzig BMC Clinical Pharmacology 2009, 9:10 (22 May 2009)
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Errors and omissions in hospital prescriptions: a survey of prescription writing in a hospital
Laura Calligaris, Angela Panzera, Luca Arnoldo, Carla Londero, Rosanna Quattrin, Maria G Troncon, Silvio Brusaferro BMC Clinical Pharmacology 2009, 9:9 (13 May 2009)
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Editor’s summary
Illegible or incomplete prescriptions for antibiotics are common in hospitals particularly in the medical and surgical sections, suggesting urgent action to increase awareness among medical staff of potential consequent medication errors is needed.
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The frequency of adverse drug reaction related admissions according to method of detection, admission urgency and medical department specialty
Miran Brvar, Nina Fokter, Matjaz Bunc, Martin Mozina BMC Clinical Pharmacology 2009, 9:8 (4 May 2009)
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Fatal drug poisonings in a Swedish general population
Anna K Jönsson, Olav Spigset, Micaela Tjäderborn, Henrik Druid, Staffan Hägg BMC Clinical Pharmacology 2009, 9:7 (27 April 2009)
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Effects of simvastatin 40 mg daily on muscle and liver adverse effects in a 5-year randomized placebo-controlled trial in 20,536 high-risk people
MRC/BHF Heart Protection Study Collaborative Group BMC Clinical Pharmacology 2009, 9:6 (31 March 2009)
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Editor’s summary
Simvastatin treatment for patients at high risk of cardiovascular events or with diabetes results in only a minor increase in the risk of myopathy and hepatobiliary diseases over 5 years of use.
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Methanol poisoning and long term sequelae – a six years follow-up after a large methanol outbreak
Raido Paasma, Knut Erik Hovda, Dag Jacobsen BMC Clinical Pharmacology 2009, 9:5 (27 March 2009)
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Editor’s summary
Six years after a large methanol poisoning outbreak in Estonia, the majority of victims still suffer from neurological impairments and visual complications, suggesting that irreversible damage has been caused by methanol consumption.
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Information about ADRs explored by pharmacovigilance approaches: a qualitative review of studies on antibiotics, SSRIs and NSAIDs
Lise Aagaard, Ebba Hansen BMC Clinical Pharmacology 2009, 9:4 (3 March 2009)
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Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series
Darren M Roberts, Renate Heilmair, Nick A Buckley, Andrew H Dawson, Mohamed Fahim, Michael Eddleston, Peter Eyer BMC Clinical Pharmacology 2009, 9:3 (16 February 2009)
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A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study
Roslyn Varki, Ed Pequignot, Mark C Leavitt, Andres Ferber, Walter K Kraft BMC Clinical Pharmacology 2009, 9:2 (28 January 2009)
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Editor’s summary
A new, egg white-derived, recombinant glycosylated colony stimulating factor is equally safe and has similar pharmacokinetic and pharmacological properties to the first commercially available colony stimulating factor when tested on healthy individuals.
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Application of microbiological assay to determine pharmaceutical equivalence of generic intravenous antibiotics
Andres F Zuluaga, Maria Agudelo, Carlos A Rodriguez, Omar Vesga BMC Clinical Pharmacology 2009, 9:1 (16 January 2009)
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Editor’s summary
Pharmaceutical equivalence of generic intravenous antibiotics can be assessed prior to their clinical use by providing information about potency and efficacy using a new microbiological assay with reference bacteria
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Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitonin
MA Karsdal, I Byrjalsen, BJ Riis, C Christiansen BMC Clinical Pharmacology 2008, 8:12 (4 December 2008)
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Systematic review of dexketoprofen in acute and chronic pain
R Andrew Moore, Jodie Barden BMC Clinical Pharmacology 2008, 8:11 (31 October 2008)
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Statins but not fibrates improve the atherogenic to anti-atherogenic lipoprotein particle ratio: a randomized crossover study
Sammy Y Chan, GB John Mancini, Andrew Ignaszewski, Jiri Frohlich BMC Clinical Pharmacology 2008, 8:10 (28 October 2008)
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How often do physicians review medication charts on ward rounds?
Khang Li Looi, Peter N Black BMC Clinical Pharmacology 2008, 8:9 (29 September 2008)
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