BMC Pharmacology | Vol 11 | 2011

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Volume 11 (2011) - October 2011

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Polyamidoamine (PAMAM) dendrimer conjugate specifically activates the A₃adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts

Tina C Wan, Dilip K Tosh, Lili Du, Elizabeth T Gizewski, Kenneth A Jacobson, John A Auchampach BMC Pharmacology 2011, 11:11 (31 October 2011)

Abstract | Full text | PDF | PubMed | Editor’s summary

A Polyamidoamine (PAMAM) dendrimer conjugated to 64 moieties of a nucleoside agonist binds to the mouse A3 adenosine receptor with enhanced potency and selectivity, and mediates cardioprotective effects in an isolated heart model of ischemia/reperfusion injury.