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Research article   Open Access Highly Accessed

A single hydrophobic cleft in the Escherichia coli processivity clamp is sufficient to support cell viability and DNA damage-induced mutagenesis in vivo

Mark D Sutton, Jill M Duzen, Sarah K Scouten Ponticelli BMC Molecular Biology 2010, 11:102 (29 December 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

The CTCF insulator protein forms an unusual DNA structure

Melissa J MacPherson, Paul D Sadowski BMC Molecular Biology 2010, 11:101 (21 December 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The zinc-finger repressor and insulator protein CTCF is able to form unusual DNA loop structures via its zinc finger domain in a directional manner and potentially function as a genome organizer.

Research article   Open Access Highly Accessed

qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3, CSF1-R, PDGFRB, MET and AXL

Jana Fassunke, Marie-Christine Blum, Hans-Ulrich Schildhaus, Marc Zapatka, Benedikt Brors, Helen Künstlinger, Reinhard Büttner, Eva Wardelmann, Sabine Merkelbach-Bruse BMC Molecular Biology 2010, 11:100 (20 December 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

A thymus-specific noncoding RNA, Thy-ncR1, is a cytoplasmic riboregulator of MFAP4 mRNA in immature T-cell lines

Kazuma Aoki, Akira Harashima, Miho Sano, Takahide Yokoi, Shuji Nakamura, Masayoshi Kibata, Tetsuro Hirose BMC Molecular Biology 2010, 11:99 (16 December 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The novel thymus-specific noncoding RNA Thy-ncR1, whose precursor exhibits complex alternative splicing patterns, has a cytoplasmic localization and functions as a riboregulator of mRNA stability during a specific stage of T-cells maturation.

Research article   Open Access Highly Accessed

Characterization, phylogeny, alternative splicing and expression of Sox30 gene

Fei Han, Zhijian Wang, Fengrui Wu, Zhihao Liu, Baofeng Huang, Deshou Wang BMC Molecular Biology 2010, 11:98 (11 December 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Structure and expression of two nuclear receptor genes in marsupials: insights into the evolution of the antisense overlap between the α-thyroid hormone receptor and Rev-erbα

Brandon C Rindfleisch, M Scott Brown, John L VandeBerg, Stephen H Munroe BMC Molecular Biology 2010, 11:97 (10 December 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Identifying novel genes in C. elegans using SAGE tags

Matthew J Nesbitt, Donald G Moerman, Nansheng Chen BMC Molecular Biology 2010, 11:96 (10 December 2010)

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Research article   Open Access Highly Accessed

Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells

Monica Guidi, Margarita Muiños-Gimeno, Birgit Kagerbauer, Eulàlia Martí, Xavier Estivill, Yolanda Espinosa-Parrilla BMC Molecular Biology 2010, 11:95 (10 December 2010)

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Research article   Open Access Highly Accessed

A mechanism for ramified rolling circle amplification

Thomas P Beals, James H Smith, Raymond M Nietupski, David J Lane BMC Molecular Biology 2010, 11:94 (7 December 2010)

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Research article   Open Access Highly Accessed

Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain

Beihui Liu, Haibo Xu, Julian FR Paton, Sergey Kasparov BMC Molecular Biology 2010, 11:93 (6 December 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Rrd1 isomerizes RNA polymerase II in response to rapamycin

Nathalie Jouvet, Jeremie Poschmann, Julie Douville, Lisa Bulet, Dindial Ramotar BMC Molecular Biology 2010, 11:92 (3 December 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Essential role for ALCAM gene silencing in megakaryocytic differentiation of K562 cells

Fang Tan, Samit Ghosh, Flaubert Mbeunkui, Robert Thomas, Joshua A Weiner, Solomon F Ofori-Acquah BMC Molecular Biology 2010, 11:91 (2 December 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Selection of reliable reference genes during THP-1 monocyte differentiation into macrophages

Marten B Maeß, Stefanie Sendelbach, Stefan Lorkowski BMC Molecular Biology 2010, 11:90 (1 December 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein

Åsne Jul-Larsen, Amra Grudic, Rolf Bjerkvig, Stig O Bøe BMC Molecular Biology 2010, 11:89 (21 November 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]

Ravi S Singh, Rishi K Gara, Pardeep K Bhardwaj, Anish Kaachra, Sonia Malik, Ravi Kumar, Madhu Sharma, Paramvir S Ahuja, Sanjay Kumar BMC Molecular Biology 2010, 11:88 (21 November 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Translational independence between overlapping genes for a restriction endonuclease and its transcriptional regulator

Meenakshi K Kaw, Robert M Blumenthal BMC Molecular Biology 2010, 11:87 (19 November 2010)

Abstract | Full text | PDF | PubMed

Methodology article   Open Access Highly Accessed

Germline transformation of the stalk-eyed fly, Teleopsis dalmanni

Ian A Warren, Kevin Fowler, Hazel Smith BMC Molecular Biology 2010, 11:86 (16 November 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access

A tryptophan-rich peptide acts as a transcription activation domain

Chen-Huan Lin, Grace Lin, Chia-Pei Chang, Chien-Chia Wang BMC Molecular Biology 2010, 11:85 (16 November 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Targeting of highly conserved Dengue virus sequences with anti-Dengue virus trans-splicing group I introns

James R Carter, James H Keith, Pradip V Barde, Tresa S Fraser, Malcolm J Fraser BMC Molecular Biology 2010, 11:84 (15 November 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Identification of amino acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA

Elena Iakhiaeva, Alexei Iakhiaev, Christian Zwieb BMC Molecular Biology 2010, 11:83 (13 November 2010)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The binding requirements of the protein and RNA components of the human signal recognition particle (SRP), the ribonucleoprotein complex that binds to the signal sequences of secretory polypeptides, have been elucidated and a model for ligand binding proposed.

Methodology article   Open Access Highly Accessed

Single-cell qPCR on dispersed primary pituitary cells -an optimized protocol

Kjetil Hodne, Trude M Haug, Finn-Arne Weltzien BMC Molecular Biology 2010, 11:82 (12 November 2010)

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Research article   Open Access

Regulation of PURA gene transcription by three promoters generating distinctly spliced 5-prime leaders: a novel means of fine control over tissue specificity and viral signals

Margaret J Wortman, Laura K Hanson, Luis Martínez-Sobrido, Ann E Campbell, Jonas A Nance, Adolfo García-Sastre, Edward M Johnson BMC Molecular Biology 2010, 11:81 (9 November 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila

Anja H Schiemann, Fang Li, Vikki M Weake, Esther J Belikoff, Kent C Klemmer, Stanley A Moore, Maxwell J Scott BMC Molecular Biology 2010, 11:80 (9 November 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Regulation of CEACAM1 transcription in human breast epithelial cells

Marieta Gencheva, Charng-Jui Chen, Tung Nguyen, John E Shively BMC Molecular Biology 2010, 11:79 (4 November 2010)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Identification of a variant form of tyrosine phosphatase LYP

Shaofeng Wang, Hongbo Dong, Jiayu Han, Wanting T Ho, Xueqi Fu, Zhizhuang J Zhao BMC Molecular Biology 2010, 11:78 (2 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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