Knock-down analysis of cug2 by morpholinosA zebrafish homologue of Cancer-upregulated gene 2 (cug2) expressed specifically in the proliferating cells of the central nervous system was identified. Morpholino-mediated knockdown of cug2 resulted in apoptosis throughout the CNS and the development of neurodegenerative phenotypes. Image shows cell death in the CNS by acridine orange staining of cug2 knock down zebrafish embryo at 28 hours post fertilization.
Taken from: Cheol-Hee Kim et al., 2011, BMC Developmental Biology [View article]
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