Galectins play a key role in avian limb skeletal morphogenesis
CG-1A, a chicken galectin closely related to mammalian galectin-1, induces ectopic cartilage formation in vivo. At 5½ days chicken wing buds were injected with CG-1A in the prospective interdigital mesenchyme between the second and third digit primordia. At 8 days, the limbs were fixed and the cartilage pattern visualized by Alcian blue staining. Ectopic cartilage in the form of a digit can be detected between the second and third digits but was not seen in control limbs injected with bovine serum albumin (BSA).
Taken from: Stuart Newman et al., 2011, BMC Developmental Biology [View article]
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