Cooperative role of Pax2 and Pax8 in mouse ear development
Loss of both Pax2 and Pax8 genes in mice (Pax2;8) prevents development of the ear past the otocyst stage (which is the structure formed by invagination of the embryonic ectodermal tissue that develops into the inner ear). Whilst Pax2 is expressed in null mice at E9.5 (magenta: as revealed by a LacZ-reporter for Pax2), much wider expression occurs, including in areas outside the partially invaginated otic placode. There is also a reduction in otocyst size and a delayed detachment from the ectoderm in Pax2;8 double null mice. Confocal images were examined and nuclei stained with DAPI (blue)..
This information is for Figure 2 part B
Taken from: Bernd Fritzsch et al., 2010, BMC Developmental Biology [View article]