Dermal integrin beta-1 is not required for hair follicle development
Loss of epithelial integrin beta-1 (Itβ1) leads to dramatic hair and skin adhesion defects including a reduction in integrin beta-4 (Itβ4) in the associated basement membrane zone. However dermal Itβ1 conditional knock-out mice display no such defects and do not show reduced Itβ4 indicating that epithelial, rather than dermal papilla Itβ1, is required for hair follicle invagination. Immunofluorescence of control murine skin indicating normal levels of Itβ4. Staining shows dermal papilla cells (anti-p75;green), Itβ4 expression (red) and cell nuclei (Hoechst dye; blue).
This information is for 6C
Taken from: Anthony Oro et al., 2010, BMC Developmental Biology [View article]
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