Confocal live whole-mount images of foxP2 enhancer B in the zebrafish brain
FOXP2 is a forkhead transcription factor regulating language development in humans, and new evidence suggests that the lef1 transcription factor regulates foxp2 expression during development of the central nervous system of zebrafish. In order to visualize in vivo expression patterns of six predicted lef1-binding foxP2 enhancers, each potential enhancer was cloned upstream of GFP. The transgenic line for the foxP2-enhancer B drove expression (shown as green fluorescence) initially in the telencephalon and then in the eye and hindbrain at 72 hours post fertilization.
Taken from: Josh Bonkowsky et al., 2008, BMC Developmental Biology [View article]