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	51. 6395 Accesses	Research article Effects of different centrifugation conditions on clinical chemistry and Immunology test results Elisabeth I Minder, Adrian Schibli, Dagmar Mahrer, Predrag Nesic, Kathrin Plüer BMC Clinical Pathology 2011, 11:6 (10 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Centrifuging heparinized blood samples for either seven minutes at 1870g or ten minutes at 2180g provides identical test results compared to those centrifuged under the same conditions for fifteen minutes as proposed by WHO.
	52. 6271 Accesses	Research article Transcriptional profiling of degraded RNA in cryopreserved and fixed tissue samples obtained at autopsy Andrew C Haller, Deepa Kanakapalli, Rosemarie Walter, Samir Alhasan, James F Eliason, Richard B Everson BMC Clinical Pathology 2006, 6:9 (4 December 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Multiplexed gene expression analyses on RNA from cryopreserved or formalin-fixed, paraffin-embedded autopsy samples can reliably be performed by the cDNA-mediated Annealing, Selection, extension and Ligation (DASL) assay, even when the RNA is degraded.
	53. 6193 Accesses	Research article Gene deletion of P-Selectin and ICAM-1 does not inhibit neutrophil infiltration into peritoneal cavity following cecal ligation-puncture Elahé T Crockett, Crystal Remelius, Karen Hess, Hayma Al-Ghawi BMC Clinical Pathology 2004, 4:2 (26 July 2004) Abstract \| Full text \| PDF \| PubMed
	54. 6127 Accesses	Research article Immunohistochemical and other prognostic factors in B cell non Hodgkin lymphoma patients, Kampala, Uganda Lynnette K Tumwine, Claudio Agostinelli, Cristina Campidelli, Emmanuel Othieno, Henry Wabinga, Simona Righi, Brunangelo Falini, Pier Piccaluga, Wilson Byarugaba, Stefano A Pileri BMC Clinical Pathology 2009, 9:11 (16 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Immunohistochemical subtyping of patients with B cell non-Hodgkin lymphoma in the resource-limited country Uganda showed that most have the clinically aggressive Burkitt lymphoma, and in these patients receiving chemotherapy is associated with good prognosis.
	55. 6026 Accesses	Research article Experiences from treatment-predictive KRAS testing; high mutation frequency in rectal cancers from females and concurrent mutations in the same tumor Mats Jönsson, Anna Ekstrand, Thomas Edekling, Jakob Eberhard, Dorthe Grabau, David Borg, Mef Nilbert BMC Clinical Pathology 2009, 9:8 (15 October 2009) Abstract \| Full text \| PDF \| PubMed
	56. 5778 Accesses	Research article Mitochondrial mosaics in the liver of 3 infants with mtDNA defects Frank Roels, Patrick Verloo, François Eyskens, Baudouin François, Sara Seneca, Boel De Paepe, Jean-Jacques Martin, Valerie Meersschaut, Marleen Praet, Emmanuel Scalais, Marc Espeel, Joél Smet, Gert Van Goethem, Rudy Van Coster BMC Clinical Pathology 2009, 9:4 (5 June 2009) Abstract \| Full text \| PDF \| PubMed
	57. 5747 Accesses	Case report Unexpected combination of acute croup and myocarditis: Case report George Briassoulis, Athina Tsorva, Emmanuel Agapitos, John Papadatos BMC Clinical Pathology 2005, 5:5 (7 June 2005) Abstract \| Full text \| PDF \| PubMed
	58. 5616 Accesses	Research article Trauma induces apoptosis in human thoracolumbar intervertebral discs Christoph-E Heyde, Sven K Tschoeke, Markus Hellmuth, Arwed Hostmann, Wolfgang Ertel, Andreas Oberholzer BMC Clinical Pathology 2006, 6:5 (23 May 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Thoracolumbar spine fractures induce apoptosis in cells of the affected intervertebral discs through activation of both the intrinsic and extrinsic apoptosis pathways.
	59. 5599 Accesses	Technical advance COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma Colin C Pritchard, Laura Akagi, Poluru L Reddy, Loren Joseph, Jonathan F Tait BMC Clinical Pathology 2010, 10:6 (26 November 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The COLD-PCR enhanced melting curve assay can detect down to 1% KRAS-mutant alleles in a wild type background and significantly improves diagnostic accuracy compared to traditional PCR and direct sequencing.
	60. 5581 Accesses	Research article Low specificity of HIV-testing on sputum specimens kept at ambient temperatures for 4 to 7 days: a blinded comparison Saidi M Egwaga, Timothy M Chonde, Mecky I Matee, Sayoki G Mfinanga, Prosper E Ngowi, Fred Lwilla, Frank GJ Cobelens BMC Clinical Pathology 2007, 7:8 (19 September 2007) Abstract \| Full text \| PDF \| PubMed
	61. 5527 Accesses	Research article Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome Yevgeniya I Shurubor, Wayne R Matson, Walter C Willett, Susan E Hankinson, Bruce S Kristal BMC Clinical Pathology 2007, 7:9 (12 November 2007) Abstract \| Full text \| PDF \| PubMed
	62. 5518 Accesses	Research article CD 9 and vimentin distinguish clear cell from chromophobe renal cell carcinoma Ariel A Williams, John PT Higgins, Hongjuan Zhao, Börje Ljungberg, James D Brooks BMC Clinical Pathology 2009, 9:9 (18 November 2009) Abstract \| Full text \| PDF \| PubMed
	63. 5507 Accesses	Research article Comparison of DNA histograms by standard flow cytometry and image cytometry on sections in Barrett's adenocarcinoma Qin Huang, Chenggong Yu, Xiaoqi Zhang, Raj K Goyal BMC Clinical Pathology 2008, 8:5 (30 May 2008) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Standard flow cytometry misses aneuploidy in nearly 30% of samples of Barretts adenocarcinoma, whereas automated high fidelity image cytometry on tissue sections detects aneuploidy in every case.
	64. 5479 Accesses	Research article Serum S100B levels after meningioma surgery: A comparison of two laboratory assays Sharon Einav, Eyal Itshayek, Jeremy D Kark, Haim Ovadia, Carolyn F Weiniger, Yigal Shoshan BMC Clinical Pathology 2008, 8:9 (19 September 2008) Abstract \| Full text \| PDF \| PubMed
	65. 5156 Accesses	Research article SNAI1 expression and the mesenchymal phenotype: an immunohistochemical study performed on 46 cases of oral squamous cell carcinoma Joerg Schwock, Grace Bradley, James C Ho, Bayardo Perez-Ordonez, David W Hedley, Jonathan C Irish, William R Geddie BMC Clinical Pathology 2010, 10:1 (5 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The transcriptional repressor protein SNAI1 is expressed at low levels in a substantial proportion of oral squamous cell carcinomas, but high expression may be associated with a poor prognosis.
	66. 5075 Accesses	Research article Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer Juho Konsti, Mikael Lundin, Heikki Joensuu, Tiina Lehtimäki, Harri Sihto, Kaija Holli, Taina Turpeenniemi-Hujanen, Vesa Kataja, Liisa Sailas, Jorma Isola, Johan Lundin BMC Clinical Pathology 2011, 11:3 (25 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An automated analysis of Ki-67 expression run on a virtual microscopy platform in breast cancer samples is comparable to visual assessment, and is a significant and independent predictor of outcome.
	67. 5069 Accesses	Research article Use of cultivation-dependent and -independent techniques to assess contamination of central venous catheters: a pilot study Mette KS Larsen, Trine R Thomsen, Claus Moser, Niels Høiby, Per H Nielsen BMC Clinical Pathology 2008, 8:10 (28 October 2008) Abstract \| Full text \| PDF \| PubMed
	68. 4972 Accesses	Research article The evaluation of renal ischaemic damage: the value of CD10 monoclonal antibody staining and of biochemical assessments of tissue viability S Tagboto, A Paul Griffiths BMC Clinical Pathology 2007, 7:5 (26 May 2007) Abstract \| Full text \| PDF \| PubMed
	69. 4962 Accesses	Research article Ex-vivo changes in amino acid concentrations from blood stored at room temperature or on ice: implications for arginine and taurine measurements Joshua S Davis, Christabelle J Darcy, Kim Piera, Yvette R McNeil, Tonia Woodberry, Nicholas M Anstey BMC Clinical Pathology 2009, 9:10 (27 November 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Arginine in whole blood samples at room temperature is rapidly degraded while taurine increases both at room temperature and on ice, so blood for amino acid analyses needs to be placed on ice or processed quickly after collection.
	70. 4882 Accesses	Research article p27^Kip1is expressed in proliferating cells in its form phosphorylated on threonine 187 Giancarlo Troncone, Juan C Martinez, Antonino Iaccarino, Pio Zeppa, Alessia Caleo, Maria Russo, Ilenia Migliaccio, Maria L Motti, Daniela Califano, Emiliano A Palmieri, Lucio Palombini BMC Clinical Pathology 2005, 5:3 (23 February 2005) Abstract \| Full text \| PDF \| PubMed
	71. 4876 Accesses	Research article Population-based study of diagnostic assays for Borrelia infection: comparison of purified flagella antigen assay (Ideia™, Dako Cytomation) and recombinant antigen assay (Liaison^®, DiaSorin) Eskild Petersen, Martin Tolstrup, Francesco Capuano, Svend Ellermann-Eriksen BMC Clinical Pathology 2008, 8:4 (18 April 2008) Abstract \| Full text \| PDF \| PubMed
	72. 4826 Accesses	Research article pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda Sam Kalungi, Solrun J Steine, Henry Wabinga, Leif Bostad, Anders Molven BMC Clinical Pathology 2009, 9:6 (19 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mutations in the RBL2 gene, which encodes the retinoblastoma protein family cell cycle protein pRb2, were not detected in Burkitt lymphoma patients from Uganda, suggesting that RBL2 mutations may be rarer in this condition than previously suggested.
	73. 4806 Accesses	Technical advance Tissue Harvester with Functional Valve (THFV): Shidham's device for reproducibly higher specimen yield by fine needle aspiration biopsy with easy to perform steps Vinod B Shidham, Ashwini W Pandit, R Nagarjun Rao, Zainab Basir, Anjani Shidham BMC Clinical Pathology 2007, 7:2 (7 March 2007) Abstract \| Full text \| PDF \| PubMed
	74. 4727 Accesses	Research article Stainable hepatic iron in 341 African American adults at coroner/medical examiner autopsy James C Barton, Ronald T Acton, Asia K Richardson, Robert M Brissie BMC Clinical Pathology 2005, 5:2 (10 January 2005) Abstract \| Full text \| PDF \| PubMed
	75. 4714 Accesses	Research article Improved Methodology for Assessment of mRNA Levels in Blood of Patients with FMR1 Related Disorders David E Godler, Danuta Z Loesch, Richard Huggins, Lavinia Gordon, Howard R Slater, Freya Gehling, Trent Burgess, KH Andy Choo BMC Clinical Pathology 2009, 9:5 (9 June 2009) Abstract \| Full text \| PDF \| PubMed
	76. 4464 Accesses	Research article Accumulation of advanced glycation end (AGEs) products in intensive care patients: an observational, prospective study Wendela L Greven, Jitty M Smit, Johannes H Rommes, Peter E Spronk BMC Clinical Pathology 2010, 10:4 (25 May 2010) Abstract \| Full text \| PDF \| PubMed
	77. 4412 Accesses	Research article Cortisol in hair measured in young adults - a biomarker of major life stressors? Jerker Karlén, Johnny Ludvigsson, Anneli Frostell, Elvar Theodorsson, Tomas Faresjö BMC Clinical Pathology 2011, 11:12 (25 October 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Increased cortisol levels in hair may serve as a biomarker of increased cortisol production reflecting exposure to major life stressors or extended physiological illness, with serious life events potentially raising hair hormone levels more than perceived stress.
	78. 4400 Accesses	Research article Tiling array-CGH for the assessment of genomic similarities among synchronous unilateral and bilateral invasive breast cancer tumor pairs Sara Brommesson, Göran Jönsson, Carina Strand, Dorthe Grabau, Per Malmström, Markus Ringnér, Mårten Fernö, Ingrid Hedenfalk BMC Clinical Pathology 2008, 8:6 (10 July 2008) Abstract \| Full text \| PDF \| PubMed
	79. 4397 Accesses	Research article Pathology of rituximab-induced Kaposi sarcoma flare Liron Pantanowitz, Klaus Früh, Sharon Marconi, Ashlee V Moses, Bruce J Dezube BMC Clinical Pathology 2008, 8:7 (23 July 2008) Abstract \| Full text \| PDF \| PubMed
	80. 4357 Accesses	Research article Use of the GenoType^®MTBDRplus assay to assess drug resistance of Mycobacterium tuberculosis isolates from patients in rural Uganda Joel Bazira, Benon B Asiimwe, Moses L Joloba, Fred Bwanga, Mecky I Matee BMC Clinical Pathology 2010, 10:5 (6 August 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The GenoType(R) MTBDRplus assay detects low levels of resistance to antibiotics in tuberculosis patients in Uganda, indicating that this technique may be suitable for use in diagnostic laboratories in countries lacking the capacity to undertake drug susceptibility testing.
	81. 4314 Accesses	Case report Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma Panagiotis A Konstantinopoulos, Bruce J Dezube, Liron Pantanowitz BMC Clinical Pathology 2006, 6:7 (30 October 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	82. 4051 Accesses	Research article Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas Yu Liang, Andrew W Bollen, M Kelly Nicholas, Nalin Gupta BMC Clinical Pathology 2005, 5:6 (15 July 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	83. 3602 Accesses	Technical advance An exfoliation and enrichment strategy results in improved transcriptional profiles when compared to matched formalin fixed samples Wilfrido D Mojica, Leighton Stein, Lesleyann Hawthorn BMC Clinical Pathology 2007, 7:7 (3 August 2007) Abstract \| Full text \| PDF \| PubMed
	84. 3442 Accesses	Research article Plasma concentrations of 25-hydroxyvitamin D among Jordanians: Effect of biological and habitual factors on vitamin D status Eyad M Mallah, Mohammad F Hamad, Mays A ElManaseer, Nidal A Qinna, Nasir M Idkaidek, Tawfiq A Arafat, Khalid Z Matalka BMC Clinical Pathology 2011, 11:8 (4 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	85. 3196 Accesses	Research article Positive hepatitis B surface antigen tests due to recent vaccination: a persistent problem Carolyn D Rysgaard, Cory S Morris, Denny Drees, Tami Bebber, Scott R Davis, Jeff Kulhavy, Matthew D Krasowski BMC Clinical Pathology 2012, 12:15 (24 September 2012) Abstract \| Full text \| PDF \| PubMed
	86. 3153 Accesses	Research article Immunohistochemical detection of laminin-1 and Ki-67 in radicular cysts and keratocystic odontogenic tumors Mohamed S Ayoub, Houry M Baghdadi, Moataz El-Kholy BMC Clinical Pathology 2011, 11:4 (2 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	87. 3132 Accesses	Research article Immunohistochemical staining of radixin and moesin in prostatic adenocarcinoma Tanner L Bartholow, Uma R Chandran, Michael J Becich, Anil V Parwani BMC Clinical Pathology 2011, 11:1 (14 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Radixin shows a lower expression level in prostatic adenocarcinoma and normal tissue adjacent to adenocarcinoma than other types of prostate tissue and it may have potential as a clinically useful biomarker.
	88. 3019 Accesses	Technical advance LeukoCatch, a quick and efficient tool for the preparation of leukocyte extracts from blood Daisuke Okuzaki, Shoichi Kimura, Norikazu Yabuta, Toshinari Ohmine, Hiroshi Nojima BMC Clinical Pathology 2011, 11:9 (17 August 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary LeukoCatch is a novel tool that can selectively obtain leukocyte extracts without hemoglobin from blood samples and results in a protein recovery rate at least four times better than that of the conventional centrifugation method.
	89. 2706 Accesses	Research article Differential effects of frozen storage on the molecular detection of bacterial taxa that inhabit the nasopharynx Brenda A Kwambana, Nuredin I Mohammed, David Jeffries, Mike Barer, Richard A Adegbola, Martin Antonio BMC Clinical Pathology 2011, 11:2 (24 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	90. 2654 Accesses	Technical advance Dual color chromogenic in situ hybridization for determination of HER2 status in breast cancer: a large comparative study to current state of the art fluorescence in situ hybridization Jens Mollerup, Ulla Henriksen, Sven Müller, Andreas Schønau BMC Clinical Pathology 2012, 12:3 (14 February 2012) Abstract \| Full text \| PDF \| PubMed
	91. 2649 Accesses	Research article Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas Sveinung W Sorbye, Thomas K Kilvaer, Andrej Valkov, Tom Donnem, Eivind Smeland, Khalid Al-Shibli, Roy M Bremnes, Lill-Tove Busund BMC Clinical Pathology 2012, 12:7 (3 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Increased co-expression of M-CSF and TGF-beta in soft tissue sarcoma, and increased expression of Ki67 in peritumoral capsule are independent negative prognostic factors for survival, suggesting that innate immunity markers may serve as prognosticators in soft tissue sarcomas.
	92. 2625 Accesses	Technical advance Molecular preservation by extraction and fixation, mPREF: a method for small molecule biomarker analysis and histology on exactly the same tissue Jeffrey R Shuster, Raymond S Lance, Dean A Troyer BMC Clinical Pathology 2011, 11:14 (21 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A modified fixation process preserves prostatectomy tissue biopsy integrity, allowing histology and multiple small molecule biomarker analyses to be performed on the same highly localised sample, enabling the distinction between normal and cancer-containing tissue specimens.
	93. 2415 Accesses	Research article Methyl-binding domain protein-based DNA isolation from human blood serum combines DNA analyses and serum-autoantibody testing Matthias Wielscher, Walter Pulverer, Johannes Peham, Manuela Hofner, Christine F Rappaport, Christian Singer, Christof Jungbauer, Christa Nöhammer, Andreas Weinhäusel BMC Clinical Pathology 2011, 11:11 (6 September 2011) Abstract \| Full text \| PDF \| PubMed
	94. 2253 Accesses	Research article Evaluation of chemiluminescence, toluidine blue and histopathology for detection of high risk oral precancerous lesions: A cross-sectional study Shweta Ujaoney, Mukta B Motwani, Shirish Degwekar, Vijay Wadhwan, Prajakta Zade, Minal Chaudhary, Vinay Hazarey, Tushar P Thakre, Manju Mamtani BMC Clinical Pathology 2012, 12:6 (12 March 2012) Abstract \| Full text \| PDF \| PubMed
	95. 2252 Accesses	Case report Intranodal palisaded myofibroblastoma originating from retroperitoneum: an unusual origin Jayesh Sagar, Athanasia Vargiamidou, Hemachandran Manikkapurath BMC Clinical Pathology 2011, 11:7 (30 June 2011) Abstract \| Full text \| PDF \| PubMed
	96. 2079 Accesses	Research article Relation of LAT1/4F2hc expression with pathological grade, proliferation and angiogenesis in human gliomas Zhen Haining, Nobuyuki Kawai, Keisuke Miyake, Masaki Okada, Shuichi Okubo, Xiang Zhang, Zhou Fei, Takashi Tamiya BMC Clinical Pathology 2012, 12:4 (28 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Large-type amino acid transporter 1 (LAT1) and heavy chain of 4F2 cell surface antigen (4F2hc) are expressed in human gliomas and their expression levels correlate with pathological grade and proliferation, with LAT1 being associated with glioma angiogenesis.
	97. 2047 Accesses	Technical advance Diagnostic accuracy of monoclonal antibody based serum immunoglobulin free light chain immunoassays in myeloma cast nephropathy Colin A Hutchison, Paul Cockwell, Mark Cook BMC Clinical Pathology 2012, 12:12 (9 August 2012) Abstract \| Full text \| PDF \| PubMed
	98. 2020 Accesses	Research article A retrospective analysis of glycol and toxic alcohol ingestion: utility of anion and osmolal gaps Matthew D Krasowski, Rebecca M Wilcoxon, Joel Miron BMC Clinical Pathology 2012, 12:1 (12 January 2012) Abstract \| Full text \| PDF \| PubMed
	99. 2009 Accesses	Research article Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia Arsen Arakelyan, Roksana Zakharyan, Aren Khoyetsyan, David Poghosyan, Rouben Aroutiounian, Frantisek Mrazek, Martin Petrek, Anna Boyajyan BMC Clinical Pathology 2011, 11:10 (25 August 2011) Abstract \| Full text \| PDF \| PubMed
	100. 1985 Accesses	Research article Prognostic impact of peritumoral lymphocyte infiltration in soft tissue sarcomas Sveinung W Sorbye, Thomas K Kilvaer, Andrej Valkov, Tom Donnem, Eivind Smeland, Khalid Al-Shibli, Roy M Bremnes, Lill-Tove Busund BMC Clinical Pathology 2012, 12:5 (29 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central