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Open Access Highly Accessed Review

Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations

Balaji VS Iyer, Martin Kenward and Gaurav Arya*

Author Affiliations

Department of NanoEngineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0448, USA

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BMC Biophysics 2011, 4:8  doi:10.1186/2046-1682-4-8

Published: 15 April 2011

Abstract

Eukaryotic genomes possess an elaborate and dynamic higher-order structure within the limiting confines of the cell nucleus. Knowledge of the physical principles and the molecular machinery that govern the 3D organization of this structure and its regulation are key to understanding the relationship between genome structure and function. Elegant microscopy and chromosome conformation capture techniques supported by analysis based on polymer models are important steps in this direction. Here, we review results from these efforts and provide some additional insights that elucidate the relationship between structure and function at different hierarchical levels of genome organization.