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Open Access Highly Accessed Editorial

Diffusion and association processes in biological systems: theory, computation and experiment

Paolo Mereghetti12, Daria Kokh1, J Andrew McCammon3 and Rebecca C Wade1*

Author Affiliations

1 Heidelberg Institute for Theoretical Studies (HITS) gGmbH, Schloss-Wolfsbrunnenweg 35, 69118 Heidelberg, Germany

2 Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Im Neuenheimer Feld 368, D-69120 Heidelberg, Germany

3 Department of Chemistry & Biochemistry, Department of Pharmacology, and NSF Center for Theoretical Biological Physics, University of California San Diego, La Jolla, CA 92093-0365, USA

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BMC Biophysics 2011, 4:2  doi:10.1186/2046-1682-4-2

Published: 2 March 2011

Abstract

Macromolecular diffusion plays a fundamental role in biological processes. Here, we give an overview of recent methodological advances and some of the challenges for understanding how molecular diffusional properties influence biological function that were highlighted at a recent workshop, BDBDB2, the second Biological Diffusion and Brownian Dynamics Brainstorm.