Experimental data-based diagram that rationalizes differentially expressed mitochondrial proteins in a tumor-stroma co-evolution model. ↑: up-regulated protein in metastatic 5-8F cells relative to nonmetastatic 6-10B cells. ↓: down-regulated protein in metastatic 5-8F cells relative to nonmetastatic 6-10B cells. The green frame means the relationship between proteins and tumor metastasis is unclear. The blue frame means the relationship between proteins and tumor metastasis is, at least partially, clear. The blue frame with solid line means protein promotes metastasis and the blue frame with dotted line means protein inhibits metastasis. SOD2, superoxide dismutase [Mn] mitochondrial isoform B; PRDX3, peroxiredoxin 3; PRDX6, peroxiredoxin 6; ECH1, mitochondrial delta(3,5)-delta(2,4)-dienoyl-CoA isomerase; SERPINB5, maspin; COX5A, mitochondrial cytochrome c oxidase subunit 5A; PDIA5, protein disulfide; EIF5A, eukaryotic initiation factor 5A; IDH3B, mitochondrial isocitrate dehydrogenase [NAD] subunit alpha; ETFA, electron transfer flavoprotein; PHB, prohibitin; MRPL12, mitochondrial ribosomal protein L7/L12; PSMC4, 26S protease regulatory subunit 7 isoform 1; VDAC1 and VDAC2, voltage-dependent anion channel 1 and 2; and CALU, calumenin isoform c precursor.
Liu et al. BMC Medical Genomics 2012 5:62 doi:10.1186/1755-8794-5-62