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This article is part of the supplement: Genetic Analysis Workshop 17: Unraveling Human Exome Data

Open Access Proceedings

A gene-based approach for testing association of rare alleles

Hongyan Xu* and Varghese George

Author Affiliations

Department of Biostatistics, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA

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BMC Proceedings 2011, 5(Suppl 9):S7  doi:10.1186/1753-6561-5-S9-S7

Published: 29 November 2011


Rare genetic variants have been shown to be important to the susceptibility of common human diseases. Methods for detecting association of rare genetic variants are drawing much attention. In this report, we applied a gene-based approach to the 200 simulated data sets of unrelated individuals. The test can detect the association of some genes with multiple rare variants.