Interactions of genes relevant to the clinical response to Platinum treatment in TCGA. Interactions of the relevant genes in F 8 are reconstructed using STRING (http://string.embl.de/ webcite). Highlighted are the chemokines family (red oval) and the Interferon and cytokines (black oval) networks. Of remarkable importance is the central role played by CXCL9 (red arrow) in orchestrating the immune and inflammatory responses, which correlate with the platinum therapy efficacy.
Liu et al. BMC Systems Biology 2013 7:14 doi:10.1186/1752-0509-7-14