Application to gene expression example. The genes of interest (458 total) were partitioned according to one or more information sources and the resulting subsets were assessed for functional significance. Each bar designates an average of p-values for all 458 genes based on a unique partitioning of the genes using one or more information sources. The publications (P), Gene Ontology (G), gene expression (E), and combinations of each are shown. The standard error bars for the averaged p-value are shown for each clustering result and the traditional level of α = 0.05 is shown for reference.
Richards et al. BMC Systems Biology 2012 6(Suppl 3):S7 doi:10.1186/1752-0509-6-S3-S7