BMC Systems Biology
Tools
Share this article

Email updates

Keep up to date with the latest news and articles from BMC Systems Biology and BioMed Central.

This article is part of the supplement: The International Conference on Intelligent Biology and Medicine (ICIBM): Systems Biology

Open Access Research

A strategy to study pathway cross-talks of cells under repetitive exposure to stimuli

Yan Fu1,2†, Xiaoshan Jiang1†, Hang Zhang1,2 and Jianhua Xing1*

  • * Corresponding author: Jianhua Xing jxing@vt.edu

  • † Equal contributors

1 Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24060, USA

2 Interdisciplinary PhD Program of Genetics, Bioinformatics and Computational Biology, Virginia Tech, Blacksburg, VA 24060, USA

For all author emails, please log on.

BMC Systems Biology 2012, 6(Suppl 3):S6 doi:10.1186/1752-0509-6-S3-S6

Published: 17 December 2012

Additional files

Additional file 1:

The maximum change distribution of regulators induced by HD or LD+HD under each priming mechanism. First column: Sample distribution in term of maximum change of x1 or x2 under HD alone (i.e., <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/S3/S6/mathml/M13','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/S3/S6/mathml/M13">View MathML</a>). Second column: distribution of changes between the maximum induction under LD+HD and the maximum induction under HD alone (i.e., <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/S3/S6/mathml/M14','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/S3/S6/mathml/M14">View MathML</a>). For PS and AI, there is a great increase in x1 under HD, but the maximum expression of x1 under LD+HD and HD alone shows no significant difference; Similarly for PS, x2 expression is enhanced by HD, whereas maximum expression of x2 under LD+HD is almost the same with that under HD alone.

Format: PDF Size: 269KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Functional clustering of genes significant increased or decreased (≥2 fold) under LD IFN-γ. The functional clustering is computed according to the enrichment of gene ontology retrieved from GOStat database. The top 10 significantly physiological functions of either LD-induced or LD-reduced genes are listed on the right. The functional clustering is computed by Cytoscape pluggin BiNGO 2.44.

Format: PDF Size: 3.4MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Biochemical reactions and parameters for the computational model.

Format: PDF Size: 251KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Variables and ordinary differentiation equations of the computational model.

Format: PDF Size: 204KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data