Figure 3.

Full network comparison of the original canonical pathway and the inferred cell-type-specific pathway. A) Provided by DREAM 4 challenge, the original canonical pathway contains 40 nodes connected by 58 edges: 4 nodes in green represent 4 cytokine receptor which originate signals; 7 nodes in blue or magenta represent observed phosphoprotein with activity measurements; 2 nodes in red represent proteins that are inhibited under some experimental conditions; and 27 hidden nodes in grey have no experimental observation; B) Predicted cell-type-specific pathway activated in HepG2 cell lines, with 37 nodes connected by 47 edges as determined by our algorithm.

Qin et al. BMC Systems Biology 2012 6(Suppl 3):S3   doi:10.1186/1752-0509-6-S3-S3