Table 3

Common cliques across the four population datasets

Clique

Enriched GOTerms

Processes(p-value)

Literature of CRC


EGFR, ESR1, GRB2, PTPN6, SHC1, SRC, PIK3R1

GO:0007173

EGFR signaling pathway (0.00253)

ESR1 [69]


GO:0071363

Cellular response to growth

GRB2 [49]


GO:0007105

Signal transduction (0.002)

EEGFR [49]


BRCA1, CREBBP, EP300, ESR1, SMAD2, SMAD3, TP53

GO:000637

Regulation of transcription from RNA polymerase II promoter (0.0044)

BRCA1 [73], CREBBP [72]


GO:0033993

Response to lipid

(0.00266)

SMAD2 [48]


GO:0031325

Positive regulation of cellular metabolic process (0.00048)

P53 [48],

EP300 [72]


CSN2, CSN3, CSN4, CSN5, CSN6, CSN7, CSN8, TP53

GO:000338

Protein deneddylation (1.7E-18)


GO:0044267

Cellular protein metabolic process (0.00029)


DIS3, EXOSC2, EXOSC4, EXOSC5, EXOSC7, EXOSC8, EXOSC9, MPP6

GO:0045006

DNA deamination

(9.47E-06)

EXOSC [81]


GO:0006304

DNA modification (0.00192)


GO:0006402

mRNA catabolic process (0.00769)


GO TERM FINDER AND DAVID level 3 (biological processes) were considered for analysis.

Pradhan et al. BMC Systems Biology 2012 6(Suppl 3):S17   doi:10.1186/1752-0509-6-S3-S17

Open Data