Overall methodology to identify the unique and common cliques in the population network. (i) Identify genes satisfying t-test in each data set. (ii) Construct networks for each dataset and annotate each node and edge in the network with its respective topological and biological features. (iii) Identify cliques of all sizes in each network and annotate each clique with its clique strength. Identify the maximum common size and highest scored clique as the seed across networks. (iv) Using the seed, identify the clique connectivity profile across networks. (v) Compare the clique connectivity profile (CCP) across network for commonality and uniqueness. (vi) Evaluate CCPs for their biological processes and pathways across networks and identify gene signatures for CRC across populations.
Pradhan et al. BMC Systems Biology 2012 6(Suppl 3):S17 doi:10.1186/1752-0509-6-S3-S17