This article is part of the supplement: Selected articles from the Third International Symposium on Optimization and Systems Biology
Proceedings
Parameter optimization by using differential elimination: a general approach for introducing constraints into objective functions
1 Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan
2 Institute of Systems Biology, Shanghai University, Shangda Road 99, Shanghai 200444, China
3 Laboratory for Bioinformatics, Graduate School of Systems Life Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
4 Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan
5 Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Osaka 560-8531, Japan
BMC Systems Biology 2010, 4(Suppl 2):S9 doi:10.1186/1752-0509-4-S2-S9
Published: 13 September 2010Additional files
Additional file 1:
According to the kinetics of the models for Models 1 and 2, the reference data of one variable, xAB (A), and that of one variable, x1 (B), were generated under the same conditions as those in Figures 2 and 5.
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Additional file 2:
The equivalent equations for Model 1 were derived from the system of differential equations by differential elimination.
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Additional file 3:
The equivalent equations for Model 2 were derived from the system of differential equations by differential elimination.
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