Table 2

Type 2 Diabetes related genes affected

Gene symbol

Corresponding protein name

Ros&Met

Met

Ros


TCF4

Transcription factor 7-like 2

Yes

No

Yes

MAPK8IP1

C-jun-amino-terminal kinase-interacting protein 1

Yes

No

Yes

NEUROD1

Neurogenic differentiation factor 1

Yes

No

Yes

HNF4A

Hepatocyte nuclear factor 4-alpha

Yes

No

No

IRS1

Insulin receptor substrate 1

Yes

No

Yes

IRS2

Insulin receptor substrate 2

No

Yes

No

AKT2

RAC-beta serine/threonine-protein kinase

No

Yes

No


AXL

Protein AXL2

Yes

No

Yes

ERBB2

Receptor tyrosine-protein kinase erbB-2

Yes

No

Yes

PCSK2

Neuroendocrine convertase 2

Yes

No

Yes

RBP4

Retinol-binding protein 4

Yes

No

Yes

SLC8A1

Sodium/calcium exchanger 1

Yes

No

Yes

IKBKAP

Elongator complex protein 1

Yes

No

No

SMARCA4

Probable global transcription activator SNF2L4

Yes

Yes

No

PMP22

Peripheral myelin protein 22

Yes

Yes

No

CSF1R

Macrophage colony-stimulating factor 1 receptor

Yes

Yes

Yes

RAG1

V(D)J recombination-activating protein 1

Yes

Yes

Yes

PLCE1

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1

Yes

Yes

No

SHC1

SHC-transforming protein 1

No

No

Yes


Type 2 Diabetes related genes affected by Ros&Met, Rosiglitazone and Metformin.

Wu et al. BMC Systems Biology 2010 4(Suppl 2):S7   doi:10.1186/1752-0509-4-S2-S7

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