Table 1

Prediction of drug combinations

Combination Drug

Score of Combination Drug

Scores of Individual Drugs

Prediction Results


Ros&Met

0.247611

(0.213158, 0.113546)

+

Ros&Chl

0.219065

(0.213158, 0.173858)

+


Ros&Tol

0.158606

(0.213158, 0.014646)

_

Ros&Phe

0.158969

(0.213158, 0.163439)

_

Tol&Chl

0.084770

(0.014646, 0.173868)

_

Tol&Phe

0.082675

(0.014646, 0.173868)

_

Tol&Met

0.084520

(0.014646, 0.163439)

_

Chl&Phe

0.161848

(0.173868, 0.163439)

_

Chl&Met

0.145706

(0.173868, 0.113546)

_

Phe&Met

0.117798

(0.163439, 0.113546)

_


Prediction of drug combinations, in which Ros, Tol, Chl, Phe and Met are the abbreviations of Rosiglitazone, Tolbutamide, Chlopropamide, Phenformin and Metformin respectively. + and _ denote effective combination and noneffective combination respectively. The scores listed in the table were obtained by setting λ to 0.5.

Wu et al. BMC Systems Biology 2010 4(Suppl 2):S7   doi:10.1186/1752-0509-4-S2-S7

Open Data