Schematic representation of the MOCO problem by dynamic thresholding of mutual information and correlation metrics. Total pairs are classified into APGs, QPGs and UPGs. The upper rightward horizontal arrow represents dynamic thresholding by mutual information, and the left descending arrow is for thresholding of the correlation measure.
Tang et al. BMC Systems Biology 2010 4(Suppl 2):S3 doi:10.1186/1752-0509-4-S2-S3