Table 4

Studies using transcriptomics

Citation

Type of study

Sample

GENE Technique

Clinical assessment

Main findings


Beech et al. 2010 [69]

Case-control

20 BPD

15 Controls

Microarray

Diagnosis based on DSM-IV criteria

SCID

HDRS

MADRS

HARS

YMRS

Altered expression of 1180 genes in patients with BPD compared with controls.

Higher expression of 559 genes and lower expression of 621 genes.

Top three functional pathways affected were the mitochondrial electron transport chain, notch signaling and NF-κβ signaling pathways.

Segman et al. 2010 [71]

Case-control

10 mothers with postpartum depression

10 control

mothers

Microarray

Diagnosis based on DSM-IV criteria

SCID

EPDS

Altered expression of 73 genes in mothers with postpartum depression compared with controls mothers.

Lower expression of 71 genes in mothers with postpartum depression including genes related to transcriptional activation, cell cycle and proliferation, nucleotide binding, and DNA replication and repair.

Kalman et al. 2005 [73]

Repeated measures

6 elderly MDD

Microarray

Diagnosis based on ICD-10 criteria

BDI

HAM-D

GDS

MMSE

Altered expression of 57 genes after 4 weeks of venlafaxine treatment when compared to baseline expression levels.

Lower expression of 26 and higher expression of 31 including genes involved in cell survival, ionic homeostasis, neural plasticity, signal transduction and metabolism

Yi et al. 2012 [74]

Case-control

8 MDD

8 SSD

8 Controls

Microarray

Diagnosis based on DSM-IV criteria

HDRS-17

Altered expression of 149 genes in patients with MDD and 1,456 genes in patients with SDD compared with controls.

Functional pathways affected included IL-2- and IL6-mediated signaling and TNF receptor signaling in patients with MDD and cytokine-cytokine receptor interactions and G protein signaling pathway in patients with SDD.


BDI: Beck Depression Inventory; BPD: bipolar disorder; BPRS: Brief Psychiatric Rating Scale; CIDI: Composite International Diagnostic Interview; DSM-IV: Diagnostic and Statistical Manual, Fourth Edition; EPDS: Edinburgh Postnatal Depression Scale; GDS: Geriatric Depression Scale; HAM-D: Hamilton Rating Scale for Depression; HDRS: Hamilton Depression Rating Scale; ICD-10: International Classification of Diseases - 10th revision; MADRS: Montgomery-Asberg Depression Rating Scale; MDD: major depressive disorder; MMSE: Mini-Mental State Examination; SCAN: Schedules for Clinical Assessment in Neuropsychiatry; SCID-I: Structured Clinical Interview for DSM-IV Axis I Disorder; SSD: subsyndromal symptomatic depression; YMRS: Young Mania Rating Scale.

Hepgul et al. BMC Medicine 2013 11:28   doi:10.1186/1741-7015-11-28

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