Table 3

Studies examining alterations in the expression of genes involved in neuroplasticity

Citation

Type of study

Sample

Gene

Clinical assessments

Main findings


Pandey et al. 2010 [45]

Case-control

25 adult MDD

25 adult controls

14 pediatric MDD

14 pediatric controls

BDNF

Diagnosis based on DSM-IV criteria

HDRS

CARS-M

CDRS

YMRS

Lower expression of BDNF in both adult and pediatric patients with MDD compared with controls.

Lower protein levels of BDNF in both adult and pediatric patients with MDD compared with controls.

Cattaneo et al. 2010a [46]

Case-control and follow up

21 MDD

23 Controls

BDNF

Diagnosis based on DSM-IV or ICD-10 criteria

MADRS

Lower expression of BDNF in patients with MDD compared with controls.

Significant increase in expression of BDNF after escitalopram treatment as well as symptom improvement.

Cattaneo et al. 2010b [48]

Case-control and follow up

25 MDD

25 Controls

VGF

Diagnosis based on DSM-IV or ICD-10 criteria

MADRS

Lower expression of VGF in patients with MDD compared with controls.

Significant increase in expression of VGF after 12 weeks of escitalopram treatment in responders only.

Cattaneo et al. 2012 [23]

Case-control and follow up

74 MDD

34 Controls

BDNF

VGF

Diagnosis based on DSM-IV or ICD-10 criteria

SCAN

Lower expression of BDNF and VGF in patients with MDD compared with controls.

Significant increase in BDNF and VGF expression after 8 weeks of antidepressant treatment (escitalopram or nortriptyline) in responders only.

Otsuki et al. 2008 [49]

Case-control

60 MDD

42 BPD

28 Controls

BDNF

NGF

NT-3

NT-4

GDNF

ARTN

NRTN

PSPN

Diagnosis based on DSM-IV criteria

HDRS

Lower expression of GDNF, ARTN and NT-3 in patients with MDD in a current depressive state compared with those in remission and controls.

No significant difference in expression of GDNF, ARTN or NT-3 in patients with BPD.

No significant difference in expression levels of BDNF, NGF or NT-3 among the three groups.

Su et al. 2009 [54]

Case-control

16 MDD

14 Controls

p11

Diagnosis based on DSM-IV criteria

MINI

HAM-D

HARS

Higher expression of p11 in patients with MDD compared with controls.

Zhang et al. 2011 [55]

Case-control

38 BPD

14 Controls

p11

Diagnosis based on DSM-IV criteria

MINI

HDRS-17

YMRS

Higher expression of p11 in patients with BPD compared with controls.

Iga et al. 2007 [57]

Case-control

42 MDD

32 Controls

VEGF

Diagnosis based on DSM-IV criteria

SIGH-D 17

Higher expression of VEGF in patients with MDD compared to controls.

Dome et al. 2009 [58]

Case-control

33 MDD

16 Controls

CD34

CD133

VEGFR2

Diagnosis based on DSM-IV criteria

BDI

Lower expression of VEGFR2 and CD133 in patients with MDD compared with controls.

Expression of VEGFR2 and CD133 correlated negatively with BDI scores.

Anitha et al. 2008 [59]

Case-control

33 MDD

21 BPD

57 Controls

PCNT2

Diagnosis based on DSM-IV criteria

BPRS

HAM-D

Higher expression of PCNT2 in patients with MDD compared with controls.

Higher expression of PCNT2 in patients with BPD in a remission state compared with controls.

Nakataki et al. 2011 [60]

Case-control

27 MDD

27 Controls

EMP1

Diagnosis based on DSM-IV criteria

HAM-D

Lower expression of EMP1 in patients with MDD compared with controls.

A trend increase in expression of EMP1 after 8 weeks of antidepressant treatment

Wakabayashi et al. 2008 [64]

Case-control

60 MDD

42 BPD

28 Controls

NCAM-140

L1

VCAM-1

ICAM-1

E-cadherin

Diagnosis based on DSM-IV criteria

HDRS

Lower expression of NCAM-140 in patients with BPD in a current depressive state, but not in a remissive state, compared with controls and patients with MDD.

Higher expression of L1 in patients with BPD in a current depressive state, but not in a remissive state, compared with controls and patients with MDD.

No significant differences in expression of NCAM-140 or L1 in patients with MDD compared with controls.

No significant differences in expression of ICAM-1, VCAM-1 or E-cadherin in patients with MDD or BPD in a current depressive state compared to controls.

Otsuki et al. 2010 [68]

Case-control

60 MDD

46 BPD

28 Controls

REST

CRH

5-HT1A

Adcy5

CaMKIIa

Epor

IGF1R

Tnfsf10

Tnfsf11

Tnfsf12-12

Diagnosis based on DSM-IV criteria

HDRS

Lower expression of REST in patients with MDD compared with controls.

Higher expression of CRH, Adcy5 and Tnfsf12-13 in patients with MDD in a current depressive state compared with those in a remissive state.

No significant difference in expression of REST or any other mRNAs in patients with BPD compared with controls.


BDI: Beck Depression Inventory; BPD: bipolar disorder; CARS-M: Clinician Administered Rating Scale for Mania; CDRS: Children Depression Rating Scale; DSM-IV: Diagnostic and Statistical Manual, Fourth Edition; HAM-D: Hamilton Rating Scale for Depression; HARS: Hamilton Anxiety Rating Scale; HDRS: Hamilton Depression Rating Scale; ICD-10: International Classification of Diseases - 10th revision; MADRS: Montgomery-Asberg Depression Rating Scale; MDD: major depressive disorder; MINI: Mini International Neuropsychiatric Interview; SIGH-D-17: Structure Interview Guide for the 17-item Hamilton Depression Rating Scale; YMRS: Young Mania Rating Scale.

Hepgul et al. BMC Medicine 2013 11:28   doi:10.1186/1741-7015-11-28

Open Data