Table 2

Studies examining alterations in the expression of genes involved in GR functionality

Citation

Type of study

Sample

Gene

Clinical assessments

Main findings


Katz et al. 2012 [35]

Repeated measures

106 pregnant women with history of depression

BAG1

CDC37L1

FKBP4

FKBP5

NCOR1

NCOA1

NR3C1

HSP70

ST13

STIP1

HSP90

P23

PPP5C

PPIA

PPID

Diagnosis based on DSM-IV criteria

SCID-I

BDI

Higher expression of BAG1, FKBP5, NCOA1 and PPID during pregnancy was diminished in patients in a current depressive state.

Cattaneo et al. 2012 [23]

Case-control and follow-up

74 MDD

34 Controls

FKBP-4

FKBP-5

GR

Diagnosis based on DSM-IV or ICD-10 criteria

SCAN

Higher expression of FKBP-5 and lower expression of GR in Patients with MDD compared with controls.

Significant decrease in FKBP-5 expression and increase in GR expression after 8 weeks of antidepressant treatment (escitalopram or nortriptyline) in responders only.

Matsubara et al. 2006 [36]

Case-control

56 MDD

48 BPD

31 Controls

GRα

GRβ

Diagnosis based on DSM-IV criteria

HDRS

Lower expression of GRα in patients with MDD in a current depressive state and in remission compared with controls.

Lower expression of GRα in patients with BPD in a current depressive state and in remission compared with controls.

No significant differences in the expression of GRβ.

Fujimoto et al. 2008 [37]

Case-control

60 MDD

46 BPD

28 Controls

Glo1

Diagnosis based on DSM-IV criteria

HDRS

Lower expression of Glo1 in patients with MDD and BPD in a current depressive state compared with controls.

No significant difference in expression of Glo1 in patients with MDD and BPD in a remissive state compared with controls.

Expression of Glo1 correlated negatively with depression scores.


BDI: Beck Depression Inventory; BPD: bipolar disorder; DSM-IV: Diagnostic and Statistical Manual, Fourth Edition; HAM-D: Hamilton Rating Scale for Depression; HDRS: Hamilton Depression Rating Scale; ICD-10: International Classification of Diseases - 10th revision; SCAN: Schedules for Clinical Assessment in Neuropsychiatry; SCID-I: Structured Clinical Interview for DSM-IV Axis I Disorder.

Hepgul et al. BMC Medicine 2013 11:28   doi:10.1186/1741-7015-11-28

Open Data