Table 4

Median biomarker levels in patient clusters.

Biomarker (units)

Median (inter quartile range) in patient clusters


blue

red

green

purple

gold


BLACK CLUSTER


CRP (ng/ml)

1.05 (0.74 to 1.33)

0.86 (<0.67 to 0.91)

1.06 (0.84 to 1.25)

<0.67 (<0.67 to 0.83)

0.75 (<0.67 to 0.90)

TNFα (pg/ml)

10.52 (7.78 to 13.25)

9.07 (7.36 to 9.79)

9.54 (7.46 to 11.78)

11.66 (8.95 to 15.48)

10.20 (8.31 to 12.820)


GREEN CLUSTER


EGF (pg/ml)

7,056 (4,965 to 13,752)

3,633 (1,874 to 5,992)

6,477 (2,784 to 10,943)

3,722.33 (3,058 to 4,956)

13,826 ( 9,488 to 20,332)

sTNFR1(pg/ml)

0.67 (0.41 to 1.04)

0.75 (0.47 to 1.05)

0.57 (0.24 to 1.61)

0.74 (0.45 to 1.06)

1.60 (0.97 to 2.54)


PURPLE CLUSTER


CK18 (ng/ml)

2.30 (0.71 to 3.59)

1.22 (0.42 to 2.78)

2.03 (0.75 to 4.33)

8.97 (2.88 to 21.43)

6.43 (2.67 to 10.28)

MCP-1 (pg/ml)

112 (38 to 212)

73 (41 to 141)

67 (28 to 113)

269 (118 to 871)

237 (106 to 550)

NSE (ng/ml)

IQR below LOD

0.28 (<0.26 to 0.92)

IQR below LOD

1.72 (<0.26 to 18.32)

0.51 (< 0.26 to 2.37)

MMP-9 (ng/ml)

IQR below LOD

IQR below LOD

IQR below LOD

15.15 (6.57 to 50.81)

IQR below LOD

IL-6 (pg/ml)

1.37 (<1.20 to 3.60)

12.93 (3.27 to 26.67)

<1.20(<1.20 to 2.50)

194.33 (16.43 to 577.33)

40.80 (4.80 to 196.67)

vWF (IU/ml) purple

0.01 (0.01 to 0.02)

0.01 (0.00 to 0.01)

0.01 (0.01 to 0.01)

0.01 (0.01 to 0.02)

0.01 (0.01 to 0.03)


GOLD CLUSTER


Protein (mg/ml)

0.07 (0.05 to 0.11)

0.44(0.29 to 0.60)

0.08 (0.05 to 0.12)

0.59 (0.25 to 0.93)

0.30 (0.09 to 1.00)

NGAL (ng/ml)

123 (92 to 212)

192 (146 to 297)

110 (74 to 148)

1,379 (602 to 1922)

464 (108 to 1368)

D-dimer (ng/ml)

<2.10 (<2.10 to 5.02)

47.01 (11.80 to 138.27)

<2.10 (<2.10 to 3.62)

597.89 (62.16 to 1493.69)

58.35 (<2.10 to 559.38)

IL-1α (pg/ml)

0.90 (0.90 to 2.52)

2.42 (1.01 to 3.53)

0.90 (0.90 to 1.01)

21.35 (5.80 to 30.93)

2.47 (0.90 to 81.00)

IL-1β (pg/ml)

IQR below LOD

IQR below LOD

IQR below LOD

17.80 (5.46 to 78.87)

<1.60 (<1.60 to 19.12)


PINK CLUSTER


IL-8 (pg/ml)

32.40 (7.93 to 265.83)

292.67 (117.33 to 604.33)

28.63 (7.90 to 135.33)

2,900 (2,064 to 2,900)

875.67 (48.40 to 2,900)

MMP9NGAL

0.09 (0.08 to 0.10)

0.16 (0.10 to 0.29)

0.07 (0.07 to 0.09)

0.29 (0.23 to 0.48)

0.23 (0.09 to 0.29)

IL-4 (pg/ml)

IQR below LOD

IQR below LOD

IQR below LOD

<6.60 (<6.60 to 6.80)

IQR below LOD

sTNFR2 (pg/ml)

IQR below LOD

<0.15 (<0.15 to 0.26)

<0.15 (<0.15 to 0.26)

IQR below LOD

<0.15 (<0.15 to 0.61)


BLUE CLUSTER


creatinine (µmol/L)

9,608 (7,961 to 13,360)

5,605 (4,454 to 11,945)

7,115 (3,868 (12,595)

7,600 (5,360 to 8,625)

14,087 (12,405 to 17,245)

osmolarity (mOsm)

536 (450 to 741)

462 (276 to 560)

526 (278 to 675)

404 (314 to 482)

644 (567 to 7,840)

TM (ng/ml)blue

4.08 (3.19 to 4.97)

3.97 (1.55 to 5.69)

4.00 (1.74 to 5.68)

3.49 (2.65 to 4.00)

6.30 (5.34 to 8.86)


YELLOW CLUSTER


IL-2 (pg/ml)

5.61 (5.21 to 5.92)

5.24 (5.02 to 5.65)

5.45 (5.20 to 6.27)

6.89 (5.99 to 7.24)

5.99 (5.65 to 7.20)

CEA (ng/ml)

1.57 (1.16 to 2.58)

1.59 (1.15 to 3.23)

1.36 (0.87 to 2.10)

1.77 (1.30 to 2.39)

1.37 (0.89 to 2.80)

HA (ng/ml)

685 (439 to 866)

835 (595 to 1005)

594 (282 to 900)

1,569 (1,143 to 1,846)

1,258 (883 to 1,712)

FPSA (ng/ml)

0.09 (0.04 to 0.21)

0.05 (0.04 to 0.23)

0.07 (0.04 to 0.12)

0.13 (0.07 to 0.30)

0.05 (0.04 to 0.10)

BTA (U/ml)

8.52 (2.57 to 38.96)

248.01 (206.82 to 394.15)

6.27 (1.21 to 17.92)

278.41 (226.40 to 504.33)

213.00 (15.24 to 476 .28)

VEGF (ng/ml)

88 (37 to 271)

96 (76 to 220)

78 (38 to 122)

1,266 (414 to 1,500)

253 (79 to 621)

FAS (pg/ml)

64 (42 to 96)

83 (60 to 128)

56 (37 to 86)

214 (106 to 475)

200 (96 to 279)


The median level and the inter-quartile range (IQR) of each biomarker in each patient cluster are shown. The biomarkers are grouped vertically to reflect how they appear in the biomarker cluster dendrogram (Figure 3). BTA, bladder tumor antigen; CEA, carcino-embryonic antigen; CK18, cytokeratin 18; CRP, C-reactive protein; EGF, epidermal growth factor; FPSA, free prostate specific antigen; HA, hyaluronidase; IL, interleukin; LOD, limit of detection; MCP-1, monocyte chemoattractant protein-1; MMP-9, matrix metalloproteinase 9; NGAL, neutrophil-associated gelatinase lipocalin; NSE, neuron specific enolase; sTNFR1, soluble tumor necrosis factor receptor 1; sTNFR2, soluble tumor necrosis factor receptor 2; TM, thrombomodulin; TNFα, tumor necrosis factor α; VEGF, vascular endothelial growth factor; vWF, Von Willeband factor.

Emmert-Streib et al. BMC Medicine 2013 11:12   doi:10.1186/1741-7015-11-12

Open Data