Table 5

List of pancreas tissue-specific proteins which have not been previously studied as serum cancer or benign disease biomarkers

Gene

Protein name

Proteome identified in:

CM proteome from pancreatic cancer cell lines [33]

Pancreatic cancer ascites proteome [32]

Pancreatic juice proteome [33]

Pancreatic tissuea

Non-pancreas proteome

Normal

Cancer


AQP8

Aquaporin 8

CTRB1

Chymotrypsinogen B1

√ Down Syndrome amniotic fluid [22]

CTRB2

Chymotrypsinogen B2

CTRC

Chymotrypsin C (caldecrin)

CUZD1

CUB and zona pellucida-like domains 1

KLK1

Kallikrein 1

PNLIPRP1

Pancreatic lipase-related protein 1

PNLIPRP2

Pancreatic lipase-related protein 2

√ CM proteome from Hep 3B [52]

PRSS3

Protease, serine, 3

√ HCC-38b; HCC-1143b; normal amniotic fluid [23]

REG1B

Regenerating islet-derived 1 beta

REG3G

Regenerating islet-derived 3 gamma

√ Seminal plasma proteome [25]

SLC30A8

Solute carrier family 30 (zinc transporter), member 8


aProteome of normal and cancer pancreatic tissue (H Kosanam et al., unpublished work); bCM proteome of breast cancer cell lines (M Pavlou et al., unpublished work). CM: conditioned media.

Prassas et al. BMC Medicine 2012 10:39   doi:10.1186/1741-7015-10-39

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