Table 4

List of lung tissue-specific proteins which have not been previously studied as serum cancer or benign disease biomarkers

Gene

Protein name

Proteome identified in:

CM proteome from lung cancer cell lines [27,52]

Non-lung proteome

IRX5

Iroquois homeobox 5

LAMP3

Lysosomal-associated membrane protein 3

MFAP4

Microfibrillar-associated protein 4

√ Normal and cancer pancreatic tissue^a, seminal plasma proteome [25]; non-malignant peritoneal fluid [26]

SCGB1A1

Secretoglobin, family 1A, member 1 (uteroglobin)

√ [22,23,25,26,31-33]

TMEM100

Transmembrane protein 100

^aProteome of normal and cancer pancreatic tissue (H Kosanam et al., unpublished work). CM: conditioned media.

Prassas et al. BMC Medicine 2012 10:39   doi:10.1186/1741-7015-10-39