Table 2

Multiplex proteomics analysis of the coronary artery disease (CAD) and normal (NOR) patient groups

Average NOR

SD

N

Average CAD

SD

N

P value


OPN

16.4 ng

15.3 ng

149

40.6 ng

38.1 ng

206

< 0.001

VCAM

980.7 ng

493.8 ng

149

1,266.5 ng

492.5 ng

206

< 0.001

APO-A1

293.7 μg

257.4 μg

91

152.5 μg

134.5 μg

135

< 0.001

IL-6

0.6 ng

1.1 ng

101

1.5 ng

1.8 pg

135

< 0.001

MPO

538.2 ng

333.9 ng

147

731.1 ng

532.5 ng

206

< 0.001

IL-1β

56.9 pg

124.0 pg

149

109.0 pg

164.0 pg

206

< 0.005

NT-pBNP

33.3 pg

59.4 pg

91

103.2 pg

204.5 pg

135

< 0.005

Fibrinogen

4.8 μg

5.8 μg

149

25.6 μg

81.6 μg

206

< 0.005

APO-B100

273.2 μg

80.6 μg

149

300.6 μg

93.0 μg

206

< 0.005

Resistin

89.5 ng

63.0 ng

149

110.7 ng

77.0 ng

206

< 0.005

CRP

1.1 μg

2.4 μg

149

3.3 μg

9.7 μg

201

< 0.005

IL-10

3.3 pg

3.7 pg

91

7.6 pg

18.4 pg

135

< 0.005

MMP1

4.7 ng

2.3 ng

91

5.3 ng

2.4 ng

135

0.015 (NS)

Leptin

13.6 ng

18.0 ng

100

10.0 ng

16.0 ng

133

0.027 (NS)

ACRP30

5.9 μg

3.9 μg

149

5.2 μg

4.0 μg

206

0.027 (NS)

MMP7

4.8 ng

3.3 ng

149

5.2 ng

2.4 ng

206

0.045 (NS)

TNFα

22.7 pg

77.1 pg

91

14.7 pg

19.3 pg

135

0.059 (NS)

IFNγ

3.6 pg

10.8 pg

149

4.7 pg

10.0 pg

206

0.069 (NS)

L-selectin

1.1 μg

0.2 μg

91

1.1 μg

0.3 μg

135

0.074 (NS)

MCP1

3.1 ng

3.7 ng

91

3.4 ng

3.4 ng

135

0.114 (NS)

PECAM-1

44.0 ng

32.1 ng

57

45.8 ng

27.2 ng

79

0.116 (NS)

TIMP1

321.3 ng

101.1 ng

91

327.2 ng

86.1 ng

135

0.116 (NS)

E-selectin

33.2 ng

19.2 ng

91

34.1 ng

16.6 ng

135

0.123 (NS)

TM

1.4 ng

0.8 ng

91

1.4 ng

0.4 ng

135

0.128 (NS)


Protein concentrations are reported in pg, ng or μg per ml of serum with adjusted P values for false discovery rate (FDR) at a cut-off for statistical significance between the NOR and CAD groups = 0.01. NS indicates that no significant statistical differences were detected with the calculated P values provided in parenthesis.

ACRP-30 = adiponectin; APO-A1 = apolipoprotein A1; APO-B100 = apolipoprotein B100; CRP = C-reactive protein; E-selectin = endothelial leukocyte adhesion molecule 1; IFNγ = interferon γ; IL = interleukin; L-selectin = leukocyte selectin; MCP-1 = monocyte chemoattractant protein 1; MMP matrix metalloproteinase; MPO = myeloperoxidase; NT-pBNP = N-terminal fragment protein precursor brain natriuretic peptide; OPN = osteopontin; PECAM-1 = platelet endothelial cell adhesion molecule 1; TIMP-1 = tissue inhibitor of metalloproteinase 1; TM = thrombomodulin; TNFα = tumor necrosis factor α; VCAM-1 = vascular cell adhesion molecule 1.

LaFramboise et al. BMC Medicine 2012 10:157   doi:10.1186/1741-7015-10-157

Open Data