Table 5

Association analysis of NPC1 haplotypes with lipid levels.

Trait

Haplotype

_{(rs1805081-rs1788799, residues)}

Whole sample

Males

Females

BETA^a

P value

BETA^a

P value

BETA^a

P value

HDL-cholesterol

GC (Arg-Ile)

-0.047

0.026

-0.070

0.017

-0.020

0.698

AG (His-Met)

-0.013

0.32

0.004

0.803

-0.0278

0.048

AC (His-Ile)

0.032

0.015

0.025

0.190

0.040

0.023

LDL-cholesterol

GC (Arg-Ile)

-0.068

0.650

-0.140

0.477

-0.034

0.877

AG (His-Met)

0.149

0.124

-0.125

0.330

0.200

0.157

AC (His-Ile)

-0.105

0.265

-0.701

0.583

-0.144

0.289

Total cholesterol

GC (Arg-Ile)

-0.011

0.408

0.003

0.872

-0.028

0.166

AG (His-Met)

0.010

0.224

0.002

0.873

0.022

0.097

AC (His-Ile)

-0.005

0.538

-0.003

0.794

-0.008

0.505

Triglycerides

GC (Arg-Ile)

0.045

0.101

0.104

0.003

-0.0313

0.466

AG (His-Met)

0.024

0.173

-0.014

0.563

0.071

0.009

AC (His-Ile)

-0.041

0.018

-0.031

0.181

-0.052

0.046

^aregression coefficient. Significant P values are in bold.

Al-Daghri et al. BMC Medicine 2012 10:140   doi:10.1186/1741-7015-10-140