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Evolutionary Medicine : clinical medicine from an evolutionary perspective

Until recently, the role of evolution in the understanding of treatment and prevention of disease had not been considered by most clinicians, but there is now growing interest in the potential clinical applicability of taking an evolutionary approach towards understanding an array of medical conditions including antibiotic resistance, obesity, psychiatric disorders, autoimmune diseases and cancer. To explore how the evolutionary aspects of health and disease can lead to the improvement of clinical medicine, BMC Medicine has launched an article collection on evolutionary medicine with guest editors Martin Brüne and Ze’ev Hochberg.

  1. Research article

    Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

    The NPC1 gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in NPC1 was associated with obesity in Eur...

    Nasser M Al-Daghri, Rachele Cagliani, Diego Forni, Majed S Alokail, Uberto Pozzoli, Khalid M Alkharfy, Shaun Sabico, Mario Clerici and Manuela Sironi

    BMC Medicine 2012 10:140

    Published on: 15 November 2012