Table 4

Association analysis of NPC1 haplotypes with T2D.

Trait

Haplotype

(rs1805081 -rs1788799, residues)

Whole sample

Males

Females


Freq.a

P value (OR)

Freq.a

P value (OR)

Freq.a

P value (OR)


T2D (all)

GC (Arg-Ile)

0.12

0.451 (1.11)

0.12

0.495 (1.14)

0.12

0.653 (1.09)

AG (His-Met)

0.41

0.009 (1.26)

0.40

0.0012 (1.54)

0.41

0.545 (1.08)

AC (His-Ile)

0.47

0.003 (0.77)

0.48

0.0004 (0.63)

0.47

0.425 (0.91)

T2D (obese)

GC (Arg-Ile)

0.12

0.577 (1.10)

0.12

0.498 (1.20)

0.12

0.780 (1.07)

AG (His-Met)

0.42

0.230 (1.14)

0.42

0.013 (1.44)

0.41

0.745 (0.95)

AC (His-Ile)

0.46

0.142 (0.85)

0.46

0.004 (0.60)

0.47

0.813 (1.03)

T2D (non-obese)

GC (Arg-Ile)

0.11

0.77 (1.07)

0.11

0.957 (1.02)

0.12

0.666 (1.19)

AG (His-Met)

0.40

0.0125 (1.46)

0.40

0.033 (1.52)

0.41

0.158 (1.40)

AC (His-Ile)

0.49

0.009 (0.67)

0.49

0.042 (0.69)

0.47

0.088 (0.65)


ahaplotype frequency. Significant P values are in bold. Freq., frequency; T2D, type 2 diabetes.

Al-Daghri et al. BMC Medicine 2012 10:140   doi:10.1186/1741-7015-10-140

Open Data