Table 3 

Association analysis of NPC1 polymorphisms with obesity, BMI, and T2D. 

Trait 
Minor allele 
Whole sample 
Males 
Females 



P value^{a} 
OR (95% CI)^{b} 
P value^{a} 
OR (95% CI)^{b} 
P value^{a} 
OR (95% CI)^{b} 



Obesity 

rs1788799 (C/G) 
G (Met) 
>0.5 
1.05 (0.87 to 1.18) 
>0.5 
1.02 (0.81 to 1.27) 
>0.5 
1.02 (0.83 to 1.27) 
rs1805081 (A/G) 
G (Arg) 
>0.5 
0.83 (0.78 to 1.25) 
>0.5 
1.06 (0.76 to 1.47) 
>0.5 
0.93 (0.67 to 1.30 
BMI 
P value^{a} 
BETA^{c} 
P value^{a} 
BETA^{c} 
P value^{a} 
BETA^{c} 

rs1788799 (C/G) 
G (Met) 
0.462 
0.328 
>0.5 
0.490 
>0.5 
0.231 
rs1805081 (A/G) 
G (Arg) 
>0.5 
0.411 
>0.5 
0.343 
>0.5 
0.450 
T2D 
P value^{a} 
OR (95% CI)^{b} 
P value^{a} 
OR (95% CI)^{b} 
P value^{a} 
OR (95% CI)^{b} 

rs1788799 (C/G) 
G (Met) 
0.027 
1.24 (1.05 to 1.48) 
0.004 
1.50 (1.15 to 1.95) 
>0.5 
1.07 (0.85 to 1.36) 
rs1805081 (A/G) 
G (Arg) 
>0.5 
1.06 (0.82 to 1.39) 
>0.5 
1.11 (0.76 to .60) 
>0.5 
1.04 (0.71 to 1.52) 


^{a}P values were calculated using logistic or linear regression (as appropriate) with an additive model; Bonferronicorrected P values are reported; nominally significant P values are in bold; ^{b}odds ratio and 95% confidence intervals refer to the minor allele. ^{c}regression coefficient. BMI, body mass index; OR, odds ratio; T2D, type 2 diabetes. 

AlDaghri et al. BMC Medicine 2012 10:140 doi:10.1186/1741701510140 