Table 3

Association analysis of NPC1 polymorphisms with obesity, BMI, and T2D.

Trait

Minor allele

Whole sample

Males

Females


P valuea

OR (95% CI)b

P valuea

OR (95% CI)b

P valuea

OR (95% CI)b


Obesity

rs1788799 (C/G)

G (Met)

>0.5

1.05 (0.87 to 1.18)

>0.5

1.02 (0.81 to 1.27)

>0.5

1.02 (0.83 to 1.27)

rs1805081 (A/G)

G (Arg)

>0.5

0.83 (0.78 to 1.25)

>0.5

1.06 (0.76 to 1.47)

>0.5

0.93 (0.67 to 1.30

BMI

P valuea

BETAc

P valuea

BETAc

P valuea

BETAc

rs1788799 (C/G)

G (Met)

0.462

0.328

>0.5

0.490

>0.5

0.231

rs1805081 (A/G)

G (Arg)

>0.5

-0.411

>0.5

-0.343

>0.5

-0.450

T2D

P valuea

OR (95% CI)b

P valuea

OR (95% CI)b

P valuea

OR (95% CI)b

rs1788799 (C/G)

G (Met)

0.027

1.24 (1.05 to 1.48)

0.004

1.50 (1.15 to 1.95)

>0.5

1.07 (0.85 to 1.36)

rs1805081 (A/G)

G (Arg)

>0.5

1.06 (0.82 to 1.39)

>0.5

1.11 (0.76 to .60)

>0.5

1.04 (0.71 to 1.52)


aP values were calculated using logistic or linear regression (as appropriate) with an additive model; Bonferroni-corrected P values are reported; nominally significant P values are in bold; bodds ratio and 95% confidence intervals refer to the minor allele. cregression coefficient. BMI, body mass index; OR, odds ratio; T2D, type 2 diabetes.

Al-Daghri et al. BMC Medicine 2012 10:140   doi:10.1186/1741-7015-10-140

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