Additional file 1.

Table S1: Likelihood ratio test statistics for models of variable selective pressure among sites. The table reports results of the likelihood ratio tests (M7 versus M8 and M8a versus M8) using the F3X4 codon frequency model. Figure S1: Multiple protein alignment of NPC1 mammalian genes. The figure shows the NPC1 multiple species alignment (41 species, Clustal format); positively selected sites and human nonsynonymous polymorphisms are highlighted. Figure S2: Branch-site random effects likelihood (branch-site REL) analysis of NPC1 genes. The figure shows a branch-site REL analysis of NPC1 with the width and color of each branch indicating the strength of selection. Figure S3: Sliding-window analysis of nucleotide diversity along NPC1 using the 1000 Genomes Project data. The figure shows θW and π calculated for Yoruba, Europeans and Asians in sliding windows of 5 kb moving along the NPC1 gene region. Figure S4: Sliding-window analysis of FST along NPC1 using the 1000 Genomes Project data. The figure shows FST (YRI/CEU/CHB-JPT) calculated in 5 kb windows moving along the NPC1 gene region.

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Al-Daghri et al. BMC Medicine 2012 10:140   doi:10.1186/1741-7015-10-140