Table 1

Characteristics of included randomized clinical trials.a

Country, trial

n

Definition of MetS

Age years

Gender

Type of intervention

Duration, years

Rate, % = number free from MetS/number subjects)

Mean difference (SE)


Intervention

Control

FBG

Waist

SBP

DBP

TG

HDL


UK, CARMEN trial [23]

46

3+ risk factors

46

M/F

LF-SC

0.5

-

-

-

0.0 (2.02)

-13.0 (5.56)

-0.6 (4.29)

50.7 (19.95)

0.5 (2.42)


UK, CARMEN trial [23]

46

≥3 MetS risk factors

46

M/F

LF-CC

0.5

-

-

-

-4.0 (2.94)

-15.0 (6.33)

-4.2 (4.29)

0.0 (16.62)

-1.5 (2.42)


USA [22]

53

Syndrome X

>29

M/F

EX+WL

0.5

-

-

-8.0 (4.84)

-

-6.0 (4.17)

-9.0 (2.08)

-17.0 (64.11)

4.0 (4.26)


Italy [21]b

164

ATP III

44

M/F

Med diet

2

20% = 18/90

67% = 60/90

-6.0 (0.35)

-2.0 (0.05)

-3.0 (0.24)

--2.0 (0.15)

-19.0 (0.90)

3.0 (0.24)


Tehran Lipid and Glucose Study [20]b

116

ATP III

41

M/F

WR

0.5

0% = 0/40

18% = 7/38

-6.0 (5.18)

0.0 (4.31)

-3.0 (5.58)

-1.0 (3.01)

-15.0 (11.34)

-6.0 (2.22)


Tehran Lipid and Glucose Study [20]b

116

ATP III

41

M/F

DASH

0.5

0% = 0/40

34% = 13/38

3.0 (5.83)

-5.0 (4.48)

-11.0 (3.80)

-6.0 (2.96)

-17.0 (11.34)

1.0 (2.16)


Part of DPPRG Study [19]

1711

ATP III

25-82 M/F

M/F

L

3

18% = 107/592

38% = 209/549

-

-

-

-

-

-


Italy [18]b

335

ATP III or hs-CRP+2

56

M/F

L

1

34% = 41/120c

65% = 77/119c

-5.9 (1.28)

-4.6 (0.64)

-6.8 (1.92)

-2.3 (1.03)

-16.0 (8.95)

3.6 (5.84)


Part of PREDIMED study [17]

499

Med diet

67

M/F

Med diet+nuts

3

16% = 41/250

25% = 63/249

-

-

-

-

-

-


Part of PREDIMED study [17]

502

Med diet

67

M/F

Med diet+V00

3

16% = 41/250

21% = 53/252

-

-

-

-

-

-


Part of Finnish DPS study [16]

502

ATPIII high risk

55

M/F

L

1

15% = 26/177

27% = 49/184

-

-

-

-

-

-


ATP III = The National Cholesterol Education Program's Adult Treatment Panel III; CARMEN = Carbohydrate Ratio Management in European National diets; DASH = The Dietary Approaches to Stop Hypertension; DBP = diastolic blood pressure; DPPRG = Diabetes Prevention Program Research Group; DPS = Diabetes Prevention Study; EX+WL = dietary and behavior modification for weight loss plus exercise; FBG = fasting blood glucose; HDL = high-density lipoprotein; hs-CRP+2 = 2 components of metabolic syndrome plus high-sensitivity CRP serum values ≥3 mg/L; L = lifestyle recommendation; LF-CC = low-fat; high-complex-carbohydrate diet; LF-SC = low-fat; high-simple-carbohydrate diet; Med = Mediterranean; MetS = metabolic syndrome; PREDIMED = Prevención con Dieta Mediterránea; SBP = systolic blood pressure; TG = triglycerides; VOO = virgin olive oil; WR = weight-reducing diet; WR+EX = weight-reducing diet plus exercise.

aStudies [20-26] were used for the meta-analysis of the metabolic syndrome components.

bSD was calculated using 95% confidence interval for references [18,20,21].

cCalculated from the proportion

Yamaoka and Tango BMC Medicine 2012 10:138   doi:10.1186/1741-7015-10-138

Open Data