Schematic summary diagram of changes in PP adipose tissue of patients with prostate cancer. Periprostatic adipose tissue of patients bearing prostate cancer likely reveals the interactions between tumor cells and adipose tissue cells. The functional repercussions of altered genes in patients with prostate cancer prompt PP adipose tissue to increased hypercellularity and decreased immunosurveillance. The resulting influence of this favorable microenvironment is to foster prostate cancer progression. Down-regulated genes are depicted in green while up-regulated genes are shown in red. ASCs, adipose-derived stem cells.
Ribeiro et al. BMC Medicine 2012 10:108 doi:10.1186/1741-7015-10-108