Open Access Highly Accessed Research article

Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue

Ricardo Ribeiro1234*, Cátia Monteiro14, Victoria Catalán35, Pingzhao Hu6, Virgínia Cunha14, Amaia Rodríguez35, Javier Gómez-Ambrosi35, Avelino Fraga127, Paulo Príncipe7, Carlos Lobato8, Francisco Lobo9, António Morais9, Vitor Silva9, José Sanches-Magalhães9, Jorge Oliveira9, Francisco Pina10, Carlos Lopes2, Rui Medeiros11124 and Gema Frühbeck1235*

Author Affiliations

1 Molecular Oncology Group, Portuguese Institute of Oncology, Ed. Laboratórios-Piso 4, Rua Dr. António Bernardino de Almeida 4200-072, Porto, Portugal

2 ICBAS, Abel Salazar Biomedical Sciences Institute, University of Porto, Rua de Jorge Viterbo Ferreira nº 228, 4050-313, Porto, Portugal

3 Metabolic Research Laboratory, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain

4 LPCC - Portuguese League Against Cancer (NRNorte), Est. Interior da Circunvalação 6657, 4200-177, Porto, Portugal

5 CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Pamplona, Spain

6 The Center for Applied Genomics, Hospital for Sick Children, MaRS Centre - East Tower 101 College Street, Room 15-705, Toronto, Ontario, M5G 1L7, Canada

7 Urology Department, Porto Hospital Centre, Largo Prof. Abel Salazar 4099-001, Porto, Portugal

8 Urology Department, D. Pedro V Military Hospital, Av. da Boavista 4150-113, Porto, Portugal

9 Urology Department, Portuguese Institute of Oncology, Rua Dr. António Bernardino de Almeida 4200-072, Porto, Portugal

10 Urology Department, S. João Hospital, Al. Prof. Hernâni Monteiro 4200 - 319, Porto, Portugal

11 CEBIMED, Faculty of Health Sciences of Fernando Pessoa University, 4200-150, Porto, Portugal

12 Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, Pío XII 36, 31008, Pamplona, Spain

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BMC Medicine 2012, 10:108  doi:10.1186/1741-7015-10-108

Published: 25 September 2012

Additional files

Additional file 1:

Additional File 1, Table S1. Significant functions with altered networks and molecules in PP adipose tissue of OB/OW subjects.

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Additional file 2:

Additional File 2, Figure S1. Representative network and genes differently expressed in OB/OW versus lean in IPA analysis. Genes are represented as nodes and the biological relationship between two nodes is represented as an edge line. Uncolored genes were not identified as differently expressed in our experiment even though they are relevant to this network. Node shape indicates enzymes (rhombus), phosphatases (triangle), kinases (inverted triangle), G-protein coupled receptor (rectangle), growth factor (square), transporter (trapezoid), transcription factor (ellipse), other (circle).

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Additional file 3:

Additional File 3, Table S2. Significant functions with altered networks and molecules in PP adipose tissue of EPCa versus BPH subjects.

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