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Open Access Highly Accessed Review

Immune mechanisms of protection: can adjuvants rise to the challenge?

Amy S McKee1, Megan KL MacLeod1, John W Kappler123 and Philippa Marrack134*

  • * Corresponding author: Philippa Marrack not@valid.com

  • † Equal contributors

Author Affiliations

1 Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA

2 Program in Biomolecular Structure, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA

3 Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA

4 Department of Biochemistry and Molecular Genetics, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA

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BMC Biology 2010, 8:37  doi:10.1186/1741-7007-8-37

Published: 12 April 2010

Abstract

For many diseases vaccines are lacking or only partly effective. Research on protective immunity and adjuvants that generate vigorous immune responses may help generate effective vaccines against such pathogens.