Diagram of the ‘mitochondrial quality control mechanism’ shows three sequential timepoints of fission and fusion. Arrows in Time 1 represent two fission events. Arrow in Time 3 represents the re-fusion of the pink fragment to the network and dissipation of its damage. The red fragment has accumulated too much damage and cannot re-fuse with the network. It will be targeted for mitophagy. Color bar represents the amount of mitochondrial damage.
Rafelski BMC Biology 2013 11:71 doi:10.1186/1741-7007-11-71