Failure by a large portion of PLHIV to take optimally ARV treatment can have serious repercussions on their health. The absence of a systematic treatment-taking promotion program in Quebec prompted stakeholders to develop jointly a theory- and evidence-based nursing intervention to this end. This article describes the results of a collective effort by researchers, clinicians and PLHIV to share their knowledge and create an appropriate intervention.
Intervention mapping was used as the framework for developing the intervention. First, the target population and environmental conditions were analyzed and a literature review conducted to identify predictors of optimal treatment taking. The predictors to emerge were self-efficacy and attitudes. Performance objectives were subsequently defined and crossed-referenced with the predictors to develop a matrix of change objectives. Then, theories of self-efficacy and persuasion (the predictors to emerge from step 1), together with practical strategies derived from these theories, were used to design the intervention. Finally, the sequence and content of the intervention activities were defined and organized, and the documentary material designed.
The intervention involves an intensive, personalized follow-up over four direct-contact sessions, each lasting 45–75 minutes. Individuals are engaged in a learning process that leads to the development of skills to motivate themselves to follow the therapeutic plan properly, to overcome situations that make taking the antiretroviral medication difficult, to cope with side-effects, to relate to people in their social circle, and to deal with health professionals.
The intervention was validated by various health professionals and pre-tested with four PLHIV. Preliminary results support the suitability and viability of the intervention. A randomized trial is currently underway to verify the effectiveness of the intervention in promoting optimal antiretroviral treatment taking.
The effectiveness of antiretroviral (ARV) treatments in improving quality of life and life expectancy among people living with HIV/AIDS (PLHIV) has been demonstrated [1-3]. However, positive results are directly related to taking ARV treatments consistently and optimally, leading to total long-term viral suppression and, in turn, immunologic recovery [4-7]. Yet, in both clinical follow-ups and the scientific literature, a significant percentage of PLHIV have been reported not to persevere with optimal treatment taking [8,9]. In Quebec, a longitudinal study  showed that at each three-month follow-up 15% to 18% of participants had not taken their ARV treatment optimally in the past seven days. After one year of follow-up, only 50% of the participants continued to take the treatments at the optimum level at each time of measurement. Furthermore, at the first forum organized by COCQ-Sida (Quebec Coalition Against Aids) in 2004, PLHIV in the province described the challenges inherent in taking ARV treatment every day and expressed their need for assistance and support in order to adopt and maintain this behaviour. Against this backdrop, an intervention to facilitate optimal ARV-treatment taking would be of benefit to PLHIV in the community.
Scientific studies evaluating interventions to optimize ARV-treatment taking are a recent phenomenon, with most having been published since 2000 [11-14]. About 20 studies have demonstrated the capacity of certain interventions to promote treatment-taking behaviour, and five of these have also observed a clinical effect. Interventions in these randomized trials were administered to individuals with the intent of providing them with medication-management skills . However, none of these interventions was based on a theoretical framework that provided a comprehensive understanding of the behaviour involved in taking an ARV treatment or laid down ways to foster this behaviour.
In the light of these findings and the fact that no systematic intervention existed for PLHIV in Quebec, a theory- and evidence-based intervention was deemed necessary to optimize ARV-treatment taking in the community. The purpose of this article is to document the results of a collective effort by researchers, clinicians and PLHIV to share and combine their knowledge in the aim of developing such an intervention.
Methods: intervention mapping
We followed the guidelines proposed by Bartholomew, Parcel, Kok and Gottlieb [16,17] in a method referred to as "intervention mapping" (IM), a stepwise approach for the development and subsequent implementation of interventions grounded in theory and empirical data. It provides a framework that affords intervention planners a systematic mode for integrating theory, research results and field data collected from the target population at each phase of intervention development. Although we present intervention mapping as a series of six steps, the process is actually iterative and cumulative. Intervention developers base each step on the previous one, moving back and forth between tasks and steps as they gain information and different perspectives from various activities.
Accordingly, researchers must first conduct a needs assessment or problem analysis. This encompasses a review of the scientific literature to identify the main determinants of health behaviour as well as an analysis of the target population and environmental conditions. Second, researchers create matrices of change objectives based both on performance objectives and on predictors of optimal behaviour. Third, theoretical foundations must be defined and underlying theoretical methods and practical strategies identified. Fourth, researchers must translate methods and strategies into an organized intervention. Fifth, researchers must plan the adoption, implementation and sustainability of the intervention. Finally, an evaluation plan must be provided for.
Step 1: Needs assessment
To gain a comprehensive understanding of the overall needs of the community of people on ARV treatment and to assess the capacity to modify their behaviour in this regard, we entered into a partnership with COCQ-Sida, a coalition of community organizations involved in the struggle against AIDS in Quebec. Our involvement in the coalition's "Treatment Adherence Committee" enabled us to collaborate with nurses, social workers, PLHIV and other stakeholders throughout the course of intervention development.
Analysis of target population and environmental conditions
The number of PLHIV in Quebec has been estimated at between 13,300 and 19,600 , with about two-thirds living in the health and social services region of Montreal . Approximately 83.4% are males of Canadian origin and the majority has had homosexual relations.
In Quebec, the public healthcare insurance system ensures universal access to health services and treatment, including ARV medication. Clinical follow-up of PLHIV is ensured by general practitioners in family-medicine clinics and by microbiologists in outpatient clinics. Such follow-up is largely medical and focuses on the clinical facets of the infection. As well, there are community groups that provide information on and peer support for HIV and treatment. However, there is no guidance or systematic intervention to foster ARV-treatment taking this population.
Analysis of behaviour
To promote optimal ARV-treatment taking, it is important to understand the behaviour and identify the factors associated with it. In their review of the literature, Ramirez-Garcia and Côté  found the most significant modifiable factors in this regard to be social support [21,22], attitudes , self-efficacy [24,25], frequency of treatment regimen , side-effects [27,28] and degree of satisfaction with health professionals [23,29].
A longitudinal study of 376 PLHIV in the target community  confirmed the importance of treatment taking and the influence of the above factors. The best predictive model included high self-efficacy, positive attitudes toward taking medication, not living alone and being male. Secondary analysis demonstrated that, of the above factors, the ones that could be improved so as to affect self-efficacy were social support and satisfaction with healthcare professionals. The same two factors and the absence of adverse side-effects also influenced attitudes. Thus, the theoretical framework of Godin et al.  was not only useful in predicting optimal medication-taking behaviour but also in explaining how such behaviour could be fostered in PLHIV.
The needs assessment culminated with the definition of the ultimate objective of the intervention, the desired behavioural outcome. For this project, it would be optimal ARV-treatment taking among PLHIV in the community.
Step 2: Matrix of intervention objectives
Objectives were further specified at this step of IM. First, the behavioural outcome was broken down into its component parts. These components parts were referred to as a performance objective. For this project, we formulated five performance objectives: follow treatment plan properly as part of daily routine, overcome situations that make taking medication difficult, cope with side-effects, relate well to those in one's personal social circle, and interact effectively with health professionals.
Finally, we formulated change objectives. These were the most immediate goals for the intervention to accomplish and were stated in terms of exactly what a person needed to learn to facilitate performing a specific behaviour. Change objectives were formulated by examining the performance objectives with regards to the predictors of optimal ARV-treatment-taking behaviour. Table 1 presents the matrix of intervention objectives for two performance objectives.
Table 1. Matrix of intervention objectives
Step 3: Theoretical methods and practical strategies
Step 3 in IM consisted in selecting useful theory-based methods to influence behaviour and the strategies to organize and operationalize the intervention methods. Two theories served as the foundation for the development of our intervention: Bandura's self-efficacy theory  and Petty and Cacioppo's persuasion theory for attitudinal change .
Bandura defined self-efficacy as an individual's belief in his or her own ability to organize and implement action to produce a desired result. He stated that individuals must have firm confidence in their abilities to undertake and follow through with the procedures necessary to succeed. He argued that individuals took action when a sense of efficacy made the effort seem worthwhile in order to attain the expected results. He further defined result expectations as opinions about the probable outcomes that actions would lead to and considered an individual's attitude to be a form of these expectations.
According to Bandura , self-efficacy is a productive characteristic that is crucial to acquiring the skills necessary to adopt a behaviour. It affects cognitive, motivational and emotional processes, and these can improve or deter performance. In view of this, skills acquisition in these areas helps not only establish behaviour considered necessary but also control the influence of these processes on learning and on behaviour. Finally, Bandura argued that self-efficacy was a contributor to the acquisition of these skills in that it relied on them to promote desired behaviour. In this intervention, four principal sources described by Bandura were used to enhance self-efficacy: sense of mastery, vicarious experiences, verbal persuasion, and management of physiological and emotional states.
According to self-efficacy theory, "mastery experiences" are the most influential means of expanding one's efficacy because they show most clearly how people can bring together the things they need to succeed. Bandura considered that mastering difficult tasks afforded people a new perspective on efficacy by increasing their confidence in their own capabilities. He regarded problem solving as a cognitive skill that facilitated learning how to master difficult tasks. For starters, he believed that the individual must learn to monitor his or her behaviour to identify conditions in which the behaviour arose. In his view, self-observation was a self-regulating motivational skill that was necessary to be able to set realistic objectives, evaluate progress and, as a result, nurture a sense of personal efficacy.
With regard to "vicarious experience," Bandura stated that evaluations of efficacy were partly influenced by the achievements of others. The more an individual identified with these others, the more influential their experiences of success became. He suggested models that taught these skills could stimulate the personal efficacy of individuals. As well, individuals could draw a greater benefit from examples in which difficulties were overcome by perseverance rather than from examples of easier tasks carried out by expert models. For Bandura, a cognitive model or visualization was a vicarious experience that influenced subsequent performance. Our intervention incorporated visualization into the problem-solving process.
Bandura  maintained that individuals verbally "persuaded" of having the skills to master certain activities were more likely to make an added effort and sustain it than self-doubting individuals were. He asserted that such verbal persuasion, which highlighted personal abilities and progress, boosted self-efficacy. He saw information about other peoples' success norms and the attribution of failure to either ineffective strategies or degree of task difficulty as persuasion strategies that strengthened the sense of self-efficacy.
Moreover, Bandura stated that people often interpreted their physiological and emotional reactions to stressful or demanding situations as signs of vulnerability or dysfunction. He believed that the skills to control these emotional reactions heightened the sense of efficacy, resulting in a corresponding improvement in performance. Hence, we included the acquisition of emotional self-management skills in our intervention.
The theoretical structure of or intervention is presented in diagram form in Figure 1. The diagram shows the matrix of relationships between the empirical basis of behaviour, such as the predictors of ARV-treatment-taking, and the theoretical basis, which recommends which skills should be developed to facilitate this behaviour.
Figure 1. Theoretical structure of intervention.
Under the Elaboration Likelihood Model proposed by Petty and Cacioppo , persuasive communication is seen as central to bringing about attitudinal change. The term "elaboration" refers to the extent to which individuals receiving a message will devote an effort to pondering its contents in shaping their attitudes. These authors describe two courses for processing information: central and peripheral.
When individuals are motivated and able to think and understand the message, the model predicts that they will follow the central course to make up their minds. However, when an individual is distraught or unmotivated, the information will be processed peripherally. Petty and Cacioppo  consider attitudes formed or changed via the central course to be relatively enduring predictors of behaviour and resistant to change. Consequently, this is the course that should be favoured for attitude reinforcement or change. To ensure the effectiveness of a persuasive message, it should therefore be framed in substantive terms and conveyed when individuals are motivated and able to concentrate on it.
When individuals are distressed or unmotivated, other peripheral mechanisms, such as the cognitive-reasoning process, the affective-conditioning process and social influence should be applied. Similarly, Petty, Wegener and Fabrigar [32,33] observed that a simple means of influencing people's attitudes in either a positive or negative direction was to ask them to analyze the positive or negative aspects of the behaviour. This cognitive process is known as self-persuasion. The authors added that repeatedly associating behaviour with positive feelings or with a stimulus that produced positive feelings (i.e., an affective "conditioning" process) could lead to positive attitudes toward the behaviour. Both of these methods were incorporated in our intervention (Table 2).
Table 2. Theories, methods and strategies regarding targeted predictors of behaviour
Step 4: Intervention
At this step, the intervention was designed by translating the theoretical methods and practical strategies into intervention documents. This intervention drew its inspiration from a philosophy of empowerment. In this approach, the PLHIV must be actively involved in seeking the information required to foster optimal ARV-treatment taking behaviour, and the health professional becomes a partner in care and a counsellor helping the individual develop the skills to facilitate this behaviour.
The intervention consisted of a customized follow-up of four 45- to 75-minute sessions with an HIV-expert nurse. The first three sessions focused on the appropriation and mobilization of specific skills in a planned order: motivational skills to follow the therapeutic plan properly and skills to cope with side-effects, including skills to identify and manage them (first session); skills for coping with negative emotions and for problem-solving to deal with situations that make taking ARV medication difficult (second session); skills for relating to people in one's social circle and for dealing with health professionals (third session). The skills thus learned were boosted in the final session.
While each session focused on specific skills, it was always possible to review those discussed previously. Different tools were utilized to facilitate use of the skills acquired, such as a chart for observing behaviours and a personal diary for recording side-effects (developed by the principal investigator and validated by HIV-expert health professionals). The individuals' understanding and use of the new skills were evaluated and positively reinforced at each session. As well, at the end of each session, the nurse suggested that the individual set objectives for the next one. These objectives would guide and motivate the individuals to integrate the skills they had learned in their daily routines and to verify their usefulness . Various documents were used to assure retention of the new information, for example, leaflets on the range of ARV treatments available  and leaflets recommending ways of dealing with adverse side-effects. Specifically, each meeting was organized and proceeded as follows.
During the first session the individual was called upon to develop and reinforce skills that would be useful in taking ARV medication as part of the daily routine. For starters, the individual was given personalized explanations on how the treatments worked, their purpose, the importance of taking them (strictly following a regular regimen), how to take them (with or without food, intervals, storing the product properly) in addition to tools and strategies to make taking medication easier (pillbox, clock radio or alarm). This educational component paved the way for the development of skills and was tailored to the individual's needs and level of awareness. This session was also designed to help develop motivational skills, such as monitoring and rewarding behaviours. Each of these was supposed to foster ARV-treatment taking.
One strategy for developing a positive attitude toward taking ARV medication was to associate each dose with a positive image or message, such as that of the sea or the sun or repeating that the medication would preserve good health longer. Assessing one's own behaviour (self-regulating skills) involved analyzing circumstances and the situation in which treatment was neglected or forgotten: "Who was I with? What was I doing?" This process would lead to finding ways to resolve the problem. Conversely, the individual analyzed situations in which he or she successfully took the medication and gained the incentive to do so again. Attaching positive significance to treatment taking would make taking medication repeatedly with a positive attitude all the easier. The final objective of the session was to enable individuals to identify and deal with adverse side-effects of the ARV treatment. With the nurse's help the side-effects were identified, as were ways of avoiding or moderating them.
The second session focused on skills to cope with negative emotions and resolve problems. As negative attitudes deter motivation and affect behaviour, they have detrimental repercussions on ARV-treatment taking. It was therefore important to be able to recognize them and keep them from persisting or intensifying. The most effective means of managing thoughts and feelings were discussed; most notably, individuals learned to repeat calming, encouraging and comforting phrases (positive messages) to themselves . As well, techniques for self-distraction, such as reading, watching films and seeking comfort from companions were reinforced.
The problem-solving process was addressed in the second part of this session to equip the individual to overcome difficult or awkward situations. This process, adapted from Sharma, Petosa and Heaney  and from Lorig and Fries , consists in: 1) describing the situation in which the oversight occurred; 2) elaborating a list of strategies for dealing with the situation; 3) choosing the strategy with the highest probability of being useful; 4) imagining oneself facing up to the situation; 5) deciding to take action and confronting the situation using this strategy; and 6) evaluating the results.
The process was presented by means of a case history, in the aim of facilitating learning through vicarious experience. It was then put into practice by the individual in a situation in which he or she found it difficult to take ARV treatment. A mnemonic technique using the first letter of each step of the process to spell out "Decide" made it easier to remember.
In this session, the focus was on mastering social skills and the skills for dealing with health professionals in order to enable individuals to mobilize formal and informal networks to assist with ARV-medication taking. Here, the nurse explained a process framed by Bergeron  that entailed identifying people likely to provide support and then establishing, reinforcing and maintaining relations with them. Thus, the individual could seek help and mobilize support.
This session began with an explanation of different types of social support (emotional, material, informational, and social integration), their importance and the impact they had on ARV-treatment taking. Next, the nurse asked the individual to think about which members of his or her social circle helped or could help with medication taking. The nurse then provided details of different community organizations involved in the struggle against AIDS and the services they offered. Strategies for creating opportunities to meet with other people, increase interaction, maintain contact and open dialogue with them were then discussed [38,39]. Two key communications skills – attentive listening and expressing feelings – were explained and demonstrated with concrete examples from daily life . The nurse then used role playing to simulate seeking aid or mobilizing social support: This activity involved making a request, listening to the other person's reaction and giving feedback on the response or support received.
In the final portion of this encounter, the nurse explained the different roles of the health professionals involved (nurse, physician, pharmacist, dietician, psychologist, and sexologist) and described situations in which their help was called for. The nurse then went over the above communication skills again to demonstrate how to deal with professionals efficiently, which entailed preparing for meetings, listening carefully when taking in information, giving and receiving feedback, and obtaining responses to questions.
A final booster session was held to reinforce the skills that had been imparted. The nurse assessed whether the objectives had been attained and offered the individual the opportunity to work further on the skills covered in previous sessions.
Details of the intervention and copies of intervention materials are available on request.
Step 5: Implementation
At this stage, it was important to ensure that the project met the needs of the target community, could be implemented and could obtain the necessary support of partners and decision-makers. The fact that this was the first time a systematic intervention to help with ARV-treatment taking had been offered had to be taken into consideration in planning how to implement it. It was important therefore to find out to what extent our designed intervention met the needs of PLHIV and was accepted by them. To this end, the content of the intervention and the documentation prepared for the participants were validated by HIV health experts: two nurses, two dieticians, a physician and a pharmacist. They used a four-point Likert-type scale to evaluate the accuracy, clarity, relevance, and importance of the information provided in the intervention and the documentation to be given to the participants. They also expressed opinions on the relevance, importance, feasibility, and acceptability of the intervention and were asked to include explanations or justifications whenever they rated items on the scale as having little or no relevance, importance, accuracy, or clarity (i.e., 1 or 2) or when they had other observations about the intervention. Generally speaking, these professionals gave the pertinence of the information provided in both the intervention and the documentation a rating of 3 or 4. Information on CD4 count and viral load, the importance of taking medication appropriately and getting around side-effects received a rating of 2 for its precision and clarity. Accordingly, we re-formulated this material with the aid of the professionals' comments (some examples are given in Table 3).
Table 3. Validation comments by HIV health experts and PLHIV
Furthermore, both the documentation and the intervention were pre-tested with four HIV-positive individuals, three men and one woman, on ARV medication. This was done to ensure that the intervention was acceptable and met the needs of PLHIV and that the language was clear with difficult and complex terms explained. They used the same Likert-type scale as the health professionals and provided comments and criticisms. These PLHIV gave the importance of the information in the intervention and the documentation a rating of 3 or 4. The small portion of the content that was rated 2 has since been modified (Table 3).
In general, all of the professionals gave the relevance, importance and suitability of the intervention and its feasibility a rating of 3 or 4. Their consensus was that the intervention was acceptable and that it was important to implement an intervention that could both foster ARV-treatment taking and that was consistent with the nature of the community. Similarly, the PLHIV expressed their satisfaction with the intervention and with the new skills it afforded them.
In order to obtain support for setting it up the intervention, COCQ-Sida assisted in contacting a family medicine clinic specialized in sexually transmitted diseases (STDs) and HIV/AIDS in Montréal. A service agreement was reached with the clinic to make our intervention available to PLHIV, in exchange for physical space for carrying it out. To facilitate cooperation with the clinic's professionals in identifying and referring participants, a number of presentations were made on the content of the intervention. A fundamental aspect of this project was its implementation by the researcher/clinician, who was present full-time in the clinic to facilitate its integration by the team of health professionals and to assist with participant recruitment.
Step 6: Evaluation plan
An experimental design was developed to evaluate the effects of the intervention. The intensive personalized follow-up over four direct-contact sessions would be compared with usual care. The usual-care intervention was not systematic. It was performed by the clinic nurse and consisted of a detailed explanation of the prescribed treatment and follow-up at the request of the PLHIV. The following hypotheses were tested: a greater proportion of participants receiving the intervention than of those in the control group would have taken their medication optimally at the T3- and T6-month follow-ups. Self-efficacy, attitudes, side-effects, social support, and relations with health professionals were mediator variables correlated with optimal treatment taking. Optimal treatment taking, the principal outcome, was evaluated on the basis of a self-administered questionnaire, viral load and CD4 count. The results of this evaluation will be published soon.
The importance of behaviour and the factors that determine it in the achievement of optimal ARV-treatment taking is widely recognized. Few studies, however, have demonstrated the effectiveness of interventions to promote optimal medication taking, in part, however, owing to the poor methodology used [14,15]. There are also gaps in the information on the development of interventions. Apparently, they have not always been founded on a solid theoretical or empirical framework and are largely derived from components of information. This information content is clearly essential, but it is not sufficient to facilitate optimal treatment taking .
Nonetheless, the authors of a recent exhaustive review of the literature  did find evidence supporting the effectiveness of some interventions in this regard. In fact, they were able to identify certain criteria for effectiveness: The interventions have to target medication-management skills and must be administered to individuals rather than to groups, and the duration of the intervention has to be at least 12 weeks. Results of other randomized trials carried out since the literature review in question also support these conclusions [42-44].
These findings justify our efforts to develop a solid theory-based nursing intervention that enables us to explain and predict behaviour that fosters optimal ARV-treatment taking. Using a systematic approach that allowed the integration of a theoretical framework, we structured our intervention on the basis of empirical and clinical data. This interweaving of different knowledge sources is an obvious strength of the mapping approach: It allows the proficiencies of all participants (researchers, clinicians and PLHIV) to converge in the development of interventions. Furthermore, we incorporated the three criteria of efficacy identified by Rueda and colleagues .
There remains only to verify the efficacy of this intervention in optimizing ARV-medication-taking behaviour. To this end, a randomized was realized. We believe that an intervention based on a solid theoretical framework aimed at the acquisition of skills necessary to manage ARV-medication will foster optimal ARV-treatment taking behaviour among PLHIV.
This article describes the results of a collective effort by researchers, clinicians and PLHIV to share their knowledge and create an intervention to promote optimal ARV-treatment taking. Intervention mapping was used as a framework for developing the intervention. The goal of the intervention was the acquisition and mobilization of skills to manage ARV-medication taking and the enhancement of self-efficacy and positive attitudes towards ARV-treatment taking, thus foster the desired behaviour.
The authors declare that they have no competing interests.
PRG and JC conceived and developed the intervention. PRG drafted the manuscript. All authors read and approved the final manuscript.
We thank all PLHIV who participated in this study. We also thank the Research Chair in Innovative Nursing Practices (Université de Montréal) for the financial support to develop this intervention.
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