Research article
Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco
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* Corresponding author: Mario Pezzotti mario.pezzotti@univr.it
1 Scientific and Technologic Department, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy
2 Department of Pathology, Section of General Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
3 Institute for Molecular Biotechnology, Biology VII, RWTH, Worringerweg 1, 52074 Aachen, Germany
4 Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Forckenbeckstrasse 6, 52074 Aachen, Germany
5 Department for Chemistry, Glycobiology Division, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
6 Department of Internal Medicine, University of Perugia, Via E. Dal Pozzo, 06126 Perugia, Italy
7 Max-Planck-Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany
8 Department for Sciences, Technologies and Markets of Grapevine and Wine, University of Verona, Via della Pieve 70, 37029 San Floriano di Valpolicella (VR), Italy
BMC Biotechnology 2009, 9:22 doi:10.1186/1472-6750-9-22
Published: 19 March 2009Additional files
Additional file 1:
Three independent primary transformants (8 weeks after transfer to soil) are shown and viral IL-10 accumulation levels, determined by ELISA, are indicated for each plant. The correlation between the viral IL-10 accumulation levels and the stunted phenotype was observed both in the T0 and T1 generation plants.
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